Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 15/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.60 |
| ▸ | NT5E | P21589 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5695007 | 1.00 | ADORA2A (0.67) | ADORA2AADORA3ADORA1ADORA2BNT5E | |
| SCHEMBL4562392 | 0.92 | ADORA2A (0.70) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL4382557 | 0.92 | ADORA2A (0.70) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL4382552 | 0.92 | ADORA2A (0.70) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL5694994 | 0.87 | ADORA2A (0.73) | ADORA2AADORA3ADORA1ADORA2BNT5E | |
| SCHEMBL5695009 | 0.87 | ADORA2A (0.73) | ADORA2AADORA3ADORA1ADORA2BNT5E | |
| SCHEMBL5695070 | 0.86 | ADORA2A (0.75) | ADORA2AADORA3ADORA1ADORA2BNT5E | |
| SCHEMBL4380797 | 0.86 | ADORA2A (0.67) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL5695057 | 0.86 | ADORA2A (0.75) | ADORA2AADORA3ADORA1ADORA2BNT5E | |
| SCHEMBL4380793 | 0.86 | ADORA2A (0.67) | ADORA2AADORA3ADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121372-B1 | ADENINE DERIVATIVES | PFIZER LTD (GB) | 2006-06-28 | — | — | EP | disclosed |
| US-6326359-B1 | PURINE DERIVATIVES | PFIZER INC | 2001-12-04 | — | — | US | disclosed |
| EP-1121372-A1 | ADENINE DERIVATIVES | Pfizer Limited (GB) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000023457-A1 | ADENINE DERIVATIVES | PFIZER LIMITED (GB) | 2000-04-27 | — | — | WO | disclosed |