Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 8/20 | 0.57 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.57 |
| ▸ | OXTR | P30559 | 5/20 | 0.57 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.57 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1465619 | 0.94 | AVPR1A (0.62) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL5366688 | 0.94 | AVPR1A (0.62) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL2501951 | 0.89 | AVPR1A (0.54) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL5349226 | 0.87 | AVPR1A (0.54) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL2499523 | 0.87 | AVPR1A (0.55) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL2493109 | 0.87 | AVPR1A (0.52) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL5070494 | 0.87 | AVPR1A (0.51) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL2500585 | 0.87 | AVPR1A (0.52) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL1465123 | 0.87 | AVPR1B (0.62) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL5347421 | 0.86 | AVPR1A (0.52) | AVPR1BAVPR1AOXTRAVPR2GPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667993-A1 | HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | Abbott GmbH & Co. KG (DE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030755-A1 | HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | ABBOTT GMBH & CO. KG (DE) | 2005-04-07 | — | — | WO | disclosed |