Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 20/20 | 0.63 |
| ▸ | EGFR | P00533 | 8/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.60 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390346 | 1.00 | ERBB2 (0.63) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4391675 | 1.00 | ERBB2 (0.63) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4389898 | 0.98 | ERBB2 (0.62) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4394985 | 0.98 | ERBB2 (0.62) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4389860 | 0.93 | ERBB2 (0.71) | ERBB2EGFRKCNH2 | |
| SCHEMBL4387827 | 0.93 | ERBB2 (0.71) | ERBB2EGFRKCNH2 | |
| SCHEMBL5696966 | 0.93 | ERBB2 (0.57) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4387541 | 0.92 | ERBB2 (0.59) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4397662 | 0.92 | ERBB2 (0.62) | ERBB2EGFRKCNH2ERBB3ERBB4 | |
| SCHEMBL4388194 | 0.92 | ERBB2 (0.62) | ERBB2EGFRKCNH2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664029-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026152-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |