Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 18/20 | 0.77 |
| ▸ | EGFR | P00533 | 13/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4388486 | 1.00 | ERBB2 (0.77) | ERBB2EGFRKCNH2 | |
| SCHEMBL5483967 | 1.00 | ERBB2 (0.77) | ERBB2EGFRKCNH2 | |
| Hydrochloric Acid SCHEMBL5697217 | 0.99 | ERBB2 (0.76) | ERBB2EGFRKCNH2 | |
| Hydrochloric Acid SCHEMBL4383996 | 0.99 | ERBB2 (0.76) | ERBB2EGFRKCNH2 | |
| SCHEMBL4385062 | 0.98 | ERBB2 (0.80) | ERBB2EGFRKCNH2 | |
| SCHEMBL5697119 | 0.98 | ERBB2 (0.80) | ERBB2EGFRKCNH2 | |
| SCHEMBL4384990 | 0.98 | ERBB2 (0.80) | ERBB2EGFRKCNH2 | |
| SCHEMBL5470352 | 0.92 | ERBB2 (0.65) | ERBB2EGFRKCNH2 | |
| Hydrochloric Acid SCHEMBL4543813 | 0.91 | ERBB2 (0.64) | ERBB2EGFRKCNH2 | |
| SCHEMBL4383950 | 0.90 | ERBB2 (0.68) | ERBB2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664029-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026152-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |