Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.33 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777252 | 0.80 | GLA (0.36) | ALDH1A1MAPT | |
| SCHEMBL17267601 | 0.78 | ESR2 (0.40) | NR1H2LMNACHRM2CHRM1CHRM3 | |
| SCHEMBL4439029 | 0.77 | NR1H2 (0.42) | NR1H2CHRM2CHRM1CHRM3ESR2 | |
| SCHEMBL31482816 | 0.77 | ESR2 (0.37) | NR1H2CHRM2CHRM1CHRM3ESR2 | |
| SCHEMBL7307321 | 0.73 | NR1H2 (0.41) | NR1H2LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL6169444 | 0.73 | NR1H2 (0.36) | NR1H2ESR2NAMPTMAPK1USP2 | |
| SCHEMBL9805766 | 0.73 | CHRM3 (0.46) | LMNACHRM2CHRM4CHRM5THRB | |
| Iodide SCHEMBL28802571 | 0.71 | CHRM3 (0.45) | LMNACHRM2CHRM4CHRM5THRB | |
| SCHEMBL1239873 | 0.71 | NR1H2 (0.39) | NR1H2THRBESR2UCHL1USP30 | |
| SCHEMBL27463224 | 0.71 | TSHR (0.37) | NR1H2LMNAESR2ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269756-A | 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E | 效应疗法股份有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-1837205-A | Process for the preparation of pyrazolopyridine tartrates | PFIZER PROD INC (US) | 2006-09-27 | — | — | CN | disclosed |
| EP-1673341-A1 | TETRAHYDROPYRIDINE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005040120-A1 | TETRAHYDROPYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2005-05-06 | — | — | WO | disclosed |