Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.53 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.53 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.53 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 3/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5697724 | 0.81 | PRKD1 (0.38) | DYRK3CDK1CDK2GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL5697747 | 0.80 | PRKD1 (0.40) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL3191993 | 0.79 | CDK2 (0.53) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL4019427 | 0.79 | CDK7 (0.79) | DYRK3CDK1CDK2GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL4060387 | 0.79 | CDK2 (0.52) | DYRK3CDK1CDK2GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL4059247 | 0.78 | CDK7 (0.78) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL4026378 | 0.78 | CDK1 (0.54) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL4063350 | 0.76 | DYRK3 (0.50) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL4059706 | 0.76 | CDK7 (0.74) | DYRK3CDK1CDK2GSK3BCDK7 | |
| SCHEMBL27620109 | 0.76 | GSK3B (0.49) | DYRK3CDK1CDK2GSK3BCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667990-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005027823-A2 | 3-HETEROCYCLYL-INDOLE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | disclosed |