Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.40 |
| ▸ | F10 | P00742 | 10/20 | 0.39 |
| ▸ | F9 | P00740 | 9/20 | 0.39 |
| ▸ | F2 | P00734 | 4/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698230 | 0.89 | F10 (0.45) | KLKB1F10F9F2PRSS1 | |
| SCHEMBL6392007 | 0.87 | F10 (0.51) | KLKB1F10F9F2PRSS1 | |
| SCHEMBL5698136 | 0.83 | F10 (0.46) | KLKB1F10F9F2PRSS1 | |
| SCHEMBL5698259 | 0.81 | KLKB1 (0.37) | KLKB1F10F9F2PRSS1 | |
| SCHEMBL5698226 | 0.79 | F10 (0.41) | KLKB1F10F9F2PRSS1 | |
| SCHEMBL5698263 | 0.77 | F10 (0.40) | KLKB1F10F9F2PRSS1 | |
| SCHEMBL5698208 | 0.76 | F10 (0.40) | KLKB1F10F9F2PRSS1 | |
| SCHEMBL5698221 | 0.76 | F10 (0.47) | KLKB1F10F9F2PRSS1 | |
| SCHEMBL6390740 | 0.75 | F10 (0.59) | KLKB1F10F9F2PRSS1 | |
| SCHEMBL5698150 | 0.73 | F10 (0.38) | F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1679073-A1 | 2-(PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID-N-4-(IMINO-HETEROCYCLYL)-PHENYL-AMIDE DERIVATIVES AND RELATES COMPOUNDS FOR USE AS INHIBITORS OF THE COAGULATION FACTORS XA AND/OR VIIA FOR TREATING THROMBOSES | MERCK PATENT GmbH (DE) | 2006-07-12 | — | — | EP | disclosed |
| EP-1517685-A1 | 2-(PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID-N-4-(THIOXO-HETEROCYCLYL)-PHENYL-AMIDE DERIVATIVES AND CORRESPONDING IMINO-HETEROCYCLYL DERIVATIVES AND RELATES COMPOUNDS FOR USE AS INHIBITORS OF THE COAGULATION FACTORS XA AND/OR VIIA FOR TREATING THROMBOSES | MERCK PATENT GmbH (DE) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004002477-A1 | 2-(PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID-N-4-(THIOXO-HETEROCYCLYL)-PHENYL-AMIDE DERIVATIVES AND CORRESPONDING IMINO-HETEROCYCLYL DERIVATIVES AND RELATES COMPOUNDS FOR USE AS INHIBITORS OF THE COAGULATION FACTORS XA AND/OR VIIA FOR TREATING THROMBOSES | MERCK PATENT GMBH (DE) | 2004-01-08 | — | — | WO | disclosed |