Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 14/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586722 | 0.86 | KLKB1 (0.64) | KLKB1CARM1 | |
| SCHEMBL22967845 | 0.86 | KLKB1 (0.54) | KLKB1CARM1 | |
| SCHEMBL21100670 | 0.85 | KLKB1 (0.56) | KLKB1CARM1 | |
| SCHEMBL18630201 | 0.84 | KLKB1 (0.52) | KLKB1CARM1 | |
| SCHEMBL22417061 | 0.84 | CARM1 (0.59) | KLKB1CARM1 | |
| SCHEMBL21919181 | 0.83 | CARM1 (0.60) | KLKB1CARM1 | |
| SCHEMBL22416926 | 0.83 | CARM1 (0.73) | KLKB1CARM1 | |
| SCHEMBL7478179 | 0.81 | KLKB1 (0.55) | KLKB1CARM1 | |
| SCHEMBL5698214 | 0.80 | KLKB1 (0.69) | KLKB1CARM1KDM4EALDH1A1 | |
| SCHEMBL4563917 | 0.80 | CARM1 (0.49) | KLKB1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1679073-A1 | 2-(PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID-N-4-(IMINO-HETEROCYCLYL)-PHENYL-AMIDE DERIVATIVES AND RELATES COMPOUNDS FOR USE AS INHIBITORS OF THE COAGULATION FACTORS XA AND/OR VIIA FOR TREATING THROMBOSES | MERCK PATENT GmbH (DE) | 2006-07-12 | — | — | EP | disclosed |