Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 20/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.74 |
| ▸ | EGFR | P00533 | 10/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569301 | 0.91 | ERBB2 (0.84) | ERBB2KCNH2EGFR | |
| SCHEMBL5487179 | 0.87 | ERBB2 (0.69) | ERBB2KCNH2EGFR | |
| SCHEMBL4486736 | 0.87 | ERBB2 (0.83) | ERBB2KCNH2EGFR | |
| SCHEMBL4493860 | 0.87 | ERBB2 (0.80) | ERBB2KCNH2EGFR | |
| SCHEMBL4480976 | 0.86 | ERBB2 (0.79) | ERBB2KCNH2EGFR | |
| SCHEMBL4485215 | 0.86 | ERBB2 (0.80) | ERBB2KCNH2EGFR | |
| SCHEMBL5699070 | 0.86 | ERBB2 (0.71) | ERBB2KCNH2EGFR | |
| SCHEMBL4474664 | 0.86 | ERBB2 (0.73) | ERBB2KCNH2EGFR | |
| SCHEMBL4471089 | 0.86 | ERBB2 (0.73) | ERBB2KCNH2EGFR | |
| SCHEMBL3815972 | 0.86 | ERBB2 (0.84) | ERBB2KCNH2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685116-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051923-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-09 | — | — | WO | disclosed |