Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 11/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 8/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.76 |
| ▸ | USP2 | O75604 | 4/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.76 |
| ▸ | TP53 | P04637 | 4/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.66 |
| ▸ | TSHR | P16473 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | ODC1 | P11926 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | GALR3 | O60755 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toxicarol SCHEMBL4742046 | 0.86 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TDP1MAPTKDM4E | |
| Toxicarol SCHEMBL25199717 | 0.86 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TDP1MAPTKDM4E | |
| SCHEMBL14273346 | 0.83 | CYP3A4 (0.80) | CYP3A4SMN1; SMN2TDP1MAPTKDM4E | |
| SCHEMBL11938491 | 0.83 | CYP3A4 (0.80) | CYP3A4SMN1; SMN2TDP1MAPTKDM4E | |
| SCHEMBL11938549 | 0.83 | CYP3A4 (0.80) | CYP3A4SMN1; SMN2TDP1MAPTKDM4E | |
| SCHEMBL19185964 | 0.83 | CYP3A4 (0.80) | CYP3A4SMN1; SMN2TDP1MAPTKDM4E | |
| SCHEMBL17188565 | 0.80 | CYP3A4 (0.77) | CYP3A4SMN1; SMN2TDP1MAPTKDM4E | |
| SCHEMBL11938548 | 0.80 | CYP3A4 (0.75) | CYP3A4SMN1; SMN2TDP1MAPTKDM4E | |
| SCHEMBL11938546 | 0.80 | CYP3A4 (0.75) | CYP3A4SMN1; SMN2TDP1MAPTKDM4E | |
| Deguelin SCHEMBL29405854 | 0.79 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2TDP1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190015423-A1 | REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-01-17 | — | — | US | claimed |
| US-20190015423-A1 | REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-01-17 | — | — | US | disclosed |
| EP-0972075-B1 | METHODS FOR ASSESSING CARDIOVASCULAR STATUS AND COMPOSITIONS FOR USE THEREOF | MEADOWLAND BUSINESS PARTNERS A (SE) | 2006-08-09 | — | — | EP | disclosed |
| US-6197505-B1 | NUCLEIC ACID DERIVED FROM HUMAN GENE WHICH ENCODES ANGIOTENSIN CONVERTING ENZYME AND WHICH IS POLYMORPHIC AT ONE OR SEVERAL POSITIONS; SCREENING FOR PREDISPOSITION; ASSESSING RESPONSIVENESS OF INDIVIDUAL TO TREATMENT REGIMEN | PYROSEQUENCING AB (SE) | 2001-03-06 | — | — | US | disclosed |