SCHEMBL570138

SCHEMBL570138

CCC(=O)O[C@H]1C[C@@]2(C)[C@@H](C[C@@H](C)[C@]2(OC(=O)c2ccco2)C(=O)CCl)[C@@H]2CCC3=CC(=O)C=C[C@]3(C)C12Cl

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.80
PGR P06401 5/20 0.80
LMNA P02545 4/20 0.80
NR3C1 P04150 4/20 0.80
ADORA3 P0DMS8 4/20 0.80
ABCB11 O95342 3/20 0.80
AR P10275 3/20 0.80
CYP2D6 P10635 2/20 0.80
CYP2C9 P11712 2/20 0.80
CYP1A2 P05177 1/20 0.80
CYP2C19 P33261 1/20 0.80
PTGS1 P23219 1/20 0.80
SLCO1B3 Q9NPD5 1/20 0.80
SLCO1B1 Q9Y6L6 1/20 0.80
USP2 O75604 4/20 0.58
MAPT P10636 3/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
NPSR1 Q6W5P4 2/20 0.58
NR1I2 O75469 2/20 0.58
MLNR O43193 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18787576 1.00 CYP3A4 (0.80) CYP3A4PGRLMNANR3C1ADORA3
SCHEMBL4569 0.94 CYP3A4 (0.84) CYP3A4PGRLMNANR3C1ADORA3
Propionic Acid SCHEMBL18787577 0.94 CYP3A4 (0.79) CYP3A4PGRLMNANR3C1ADORA3
Water SCHEMBL142488 0.94 CYP3A4 (0.83) CYP3A4PGRLMNANR3C1ADORA3
SCHEMBL6667323 0.93 CYP3A4 (0.82) CYP3A4PGRLMNANR3C1ADORA3
Furan SCHEMBL5473562 0.91 CYP3A4 (0.78) CYP3A4PGRLMNANR3C1ADORA3
SCHEMBL4444301 0.90 CYP3A4 (0.76) CYP3A4PGRLMNANR3C1ADORA3
Mometasone Furoate SCHEMBL25382496 0.89 CYP3A4 (1.00) CYP3A4PGRLMNANR3C1ADORA3
Mometasone Furoate SCHEMBL2594997 0.89 CYP3A4 (1.00) CYP3A4PGRLMNANR3C1ADORA3
Mometasone Furoate SCHEMBL8826257 0.89 CYP3A4 (1.00) CYP3A4PGRLMNANR3C1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112933064-A Salmeterol xinafoate particle for inhalation and preparation method thereof 深圳市海滨制药有限公司 2021-06-11 CN claimed
EP-1455873-A1 METERED DOSE INHALER CHIESI FARMACEUTICI S.p.A. (IT) 2004-09-15 EP claimed
US-20030178022-A1 Pressurized metered dose inhaler (PMDI) actuators and medicinal aerosol solution formulation products comprising therse actuators CHIESI FARMACEUTICI S.P.A. 2003-09-25 US claimed
WO-2003053501-A1 METERED DOSE INHALER CHIESI FARMACEUTICI S.P.A. (IT) 2003-07-03 WO claimed
EP-1321159-A1 Pressurized metered dose inhaler (pMDI) actuators with laser drilled orifices CHIESI FARMACEUTICI S.p.A. (IT) 2003-06-25 EP claimed
US-20230181555-A1 STABLE AND PRESERVED PHARMACEUTICAL COMPOSITIONS OF BILASTINE FAES FARMA, S.A. (ES) 2023-06-15 US disclosed
US-11642309-B2 Aqueous compositions comprising bilastine and mometasone FAES FARMA, S.A. (ES) 2023-05-09 US disclosed
CN-114390928-A Methods of treating ocular neovascular diseases using AAV2 variants encoding aflibercept 阿德夫拉姆生物技术股份有限公司 2022-04-22 CN disclosed
CN-114375195-A Methods of treating ocular neovascular diseases using AAV2 variants encoding aflibercept 阿德夫拉姆生物技术股份有限公司 2022-04-19 CN disclosed
CN-114007588-A Stable and preserved pharmaceutical composition of bilastine 费斯制药股份有限公司 2022-02-01 CN disclosed
US-20210186869-A1 AQUEOUS COMPOSITIONS COMPRISING BILASTINE AND MOMETASONE FAES FARMA, S.A. (ES) 2021-06-24 US disclosed
CN-112933064-A Salmeterol xinafoate particle for inhalation and preparation method thereof 深圳市海滨制药有限公司 2021-06-11 CN disclosed
WO-2019076798-A1 AQUEOUS COMPOSITIONS COMPRISING BILASTINE AND MOMETASONE FAES FARMA, S.A. (ES) 2019-04-25 WO disclosed
WO-2017091167-A1 TOPICAL PHARMACEUTICAL COMPOSITION COMPRISING FUSIDIC ACID, ISOCONAZOLE, DEXPANTHENOL AND HYDROCORTISONE PHARMACTİVE İLAÇ SAN. VE TİC. A.Ş. (TR) 2017-06-01 WO disclosed
WO-2012023082-A1 A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, A CORTICOSTEROID - HYDROCORTISONE ACETATE, AND AN ANTIFUNGAL AGENT - TERBINAFINE HYDROCHLORIDE, AND A PROCESS TO MAKE IT VANANGAMUDI SULUR SUBRAMANIAM (IN) 2012-02-23 WO disclosed
WO-2012017370-A1 A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, BETAMETHASONE DIPROPIONATE, TERBINAFINE HYDROCHLORIDE AND A PROCESS TO MAKE IT VANANGAMUDI SULUR SUBRAMANIAM (IN) 2012-02-09 WO disclosed
EP-1455873-A1 METERED DOSE INHALER CHIESI FARMACEUTICI S.p.A. (IT) 2004-09-15 EP disclosed
US-20030178022-A1 Pressurized metered dose inhaler (PMDI) actuators and medicinal aerosol solution formulation products comprising therse actuators CHIESI FARMACEUTICI S.P.A. 2003-09-25 US disclosed
WO-2003053501-A1 METERED DOSE INHALER CHIESI FARMACEUTICI S.P.A. (IT) 2003-07-03 WO disclosed
EP-1321159-A1 Pressurized metered dose inhaler (pMDI) actuators with laser drilled orifices CHIESI FARMACEUTICI S.p.A. (IT) 2003-06-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210186869-A1 AQUEOUS COMPOSITIONS COMPRISING BILASTINE AND MOMETASONE HRH4, HRH2, HRH1 CYP3A4 196/4885PGR 752/4885LMNA 4077/4885
US-20230181555-A1 STABLE AND PRESERVED PHARMACEUTICAL COMPOSITIONS OF BILASTINE HRH4, CNR2, CNR1 CYP3A4 249/4885PGR 2182/4885LMNA 2539/4885
US-11642309-B2 Aqueous compositions comprising bilastine and mometasone HRH4, HRH2, HRH1 CYP3A4 196/4885PGR 752/4885LMNA 4077/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.