Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL124913 | 0.96 | PTGS1 (0.60) | PTGS1GAAALDH1A1PKMLMNA | |
| SCHEMBL9352293 | 0.96 | PTGS1 (0.66) | PTGS1GAAALDH1A1PKMLMNA | |
| SCHEMBL9356000 | 0.96 | PTGS1 (0.60) | PTGS1GAAALDH1A1PKMLMNA | |
| Zinc Ion SCHEMBL587456 | 0.96 | PTGS1 (0.60) | PTGS1GAAALDH1A1PKMLMNA | |
| SCHEMBL15234431 | 0.96 | PTGS1 (0.60) | PTGS1GAAALDH1A1PKMLMNA | |
| Lithium Ion SCHEMBL4365114 | 0.96 | PTGS1 (0.60) | PTGS1GAAALDH1A1PKMLMNA | |
| SCHEMBL7760538 | 0.96 | PTGS1 (0.60) | PTGS1GAAALDH1A1PKMLMNA | |
| Potassium Ion SCHEMBL10353844 | 0.96 | PTGS1 (0.60) | PTGS1GAAALDH1A1PKMLMNA | |
| SCHEMBL3833140 | 0.94 | PTGS1 (0.58) | PTGS1GAAALDH1A1PKMLMNA | |
| Tetramethylammonium Ion SCHEMBL4365214 | 0.92 | PTGS1 (0.56) | PTGS1GAAALDH1A1PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3265467-B1 | ORGANOMETALLIC COMPOUND | UMICORE AG & CO KG (DE) | 2018-10-17 | — | — | EP | claimed |
| EP-3265467-A1 | ORGANOMETALLIC COMPOUND | Umicore AG & Co. KG (DE) | 2018-01-10 | — | — | EP | claimed |
| WO-2016142199-A1 | ORGANOMETALLIC COMPOUND | UMICORE AG & CO. KG (DE) | 2016-09-15 | — | — | WO | claimed |
| EP-2616499-B1 | QUATERNISED POLYBENZIMIDAZOLE | COUNCIL SCIENT IND RES (IN) | 2015-03-11 | — | — | EP | claimed |
| WO-2014191115-A1 | DYEING OF KERATIN FIBERS BY MEANS OF NOBLE-METAL COMPOUNDS | HENKEL AG & CO. KGAA (DE) | 2014-12-04 | — | — | WO | claimed |
| EP-2582238-B1 | COMPOSITIONS OF DIBROMOMALONAMIDE AND THEIR USE AS BIOCIDES | DOW GLOBAL TECHNOLOGIES LLC (US) | 2014-06-04 | — | — | EP | claimed |
| EP-0636938-B1 | Silver halide light-sensitive material comprising polymerizable layer provided on aluminum support | FUJI PHOTO FILM CO LTD (JP) | 1996-05-08 | — | — | EP | claimed |
| EP-2914563-B1 | PRINTING PROCESS | WZR CERAM SOLUTIONS GMBH (DE) | 2021-06-30 | — | — | EP | disclosed |
| EP-3265467-B1 | ORGANOMETALLIC COMPOUND | UMICORE AG & CO KG (DE) | 2018-10-17 | — | — | EP | disclosed |
| EP-3265467-A1 | ORGANOMETALLIC COMPOUND | Umicore AG & Co. KG (DE) | 2018-01-10 | — | — | EP | disclosed |
| EP-2888221-B1 | METHOD FOR PRODUCING ACETYLENEDICARBOXYLIC ACID FROM ACETYLENE AND CARBON DIOXIDE | BASF SE (DE) | 2016-11-02 | — | — | EP | disclosed |
| WO-2016142199-A1 | ORGANOMETALLIC COMPOUND | UMICORE AG & CO. KG (DE) | 2016-09-15 | — | — | WO | disclosed |
| EP-2914563-A1 | PRESSURE PROCESS | WZR Ceramic Solutions GmbH (DE) | 2015-09-09 | — | — | EP | disclosed |
| EP-2888221-A1 | METHOD FOR PRODUCING ACETYLENEDICARBOXYLIC ACID FROM ACETYLENE AND CARBON DIOXIDE | BASF SE (DE) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014191115-A1 | DYEING OF KERATIN FIBERS BY MEANS OF NOBLE-METAL COMPOUNDS | HENKEL AG & CO. KGAA (DE) | 2014-12-04 | — | — | WO | disclosed |
| WO-2014067990-A1 | PRESSURE PROCESS | WZR ceramic solutions GmbH (DE) | 2014-05-08 | — | — | WO | disclosed |
| WO-2014029689-A1 | METHOD FOR PRODUCING ACETYLENEDICARBOXYLIC ACID FROM ACETYLENE AND CARBON DIOXIDE | BASF SE (DE) | 2014-02-27 | — | — | WO | disclosed |
| EP-1710229-A2 | Process for the preparation of aromatic sulfonic anhydrides | Saltigo GmbH (DE) | 2006-10-11 | — | — | EP | disclosed |