Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GNRHR | P30968 | 7/20 | 0.44 |
| ▸ | FPR1 | P21462 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5265419 | 0.93 | HTT (0.56) | HTTRAB9ANPC1ALDH1A1NPSR1 | |
| SCHEMBL5705545 | 0.86 | GNRHR (0.46) | RAB9ANPC1ALDH1A1GNRHRSMN1; SMN2 | |
| SCHEMBL5705276 | 0.81 | GNRHR (0.71) | ALDH1A1MAPTKDM4EPOLBGNRHR | |
| SCHEMBL14508366 | 0.79 | GNRHR (0.43) | GNRHRFPR1GPR183GPR119 | |
| SCHEMBL5834348 | 0.79 | GNRHR (0.68) | GNRHRFPR1GPR183GPR119 | |
| SCHEMBL5264734 | 0.75 | GNRHR (0.59) | ALDH1A1MAPTHSD17B10POLBGNRHR | |
| SCHEMBL5266205 | 0.74 | GNRHR (0.71) | ALDH1A1MAPTKDM4EPOLBGNRHR | |
| SCHEMBL12018996 | 0.74 | HTT (1.00) | HTTRAB9ANPC1ALDH1A1NPSR1 | |
| SCHEMBL5266033 | 0.73 | GNRHR (0.53) | ALDH1A1GNRHRFPR1GPR183GPR119 | |
| SCHEMBL5267626 | 0.73 | GNRHR (0.56) | ALDH1A1MAPTHSD17B10POLBGNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562611-B1 | HETEROCYCLIC SILICON COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASES OR CONDITIONS ASSOCIATED WITH GNRH (GONADOTROPIN-RELEASING HORMONE) | PARADIGM THERAPEUTICS LTD (GB) | 2006-08-02 | — | — | EP | disclosed |