SCHEMBL5705358

SCHEMBL5705358

CC(C)(CCCCCC(=O)CCCCCC(C)(c1ccccc1)C(O)O)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.35
HIF1A Q16665 1/20 0.35
FFAR4 Q5NUL3 1/20 0.34
TAAR1 Q96RJ0 1/20 0.34
HDAC1 Q13547 4/20 0.33
HDAC3 O15379 3/20 0.33
HDAC4 P56524 3/20 0.33
HDAC7 Q8WUI4 3/20 0.33
HDAC2 Q92769 3/20 0.33
HDAC10 Q969S8 3/20 0.33
HDAC11 Q96DB2 3/20 0.33
HDAC8 Q9BY41 3/20 0.33
HDAC6 Q9UBN7 3/20 0.33
HDAC9 Q9UKV0 3/20 0.33
HDAC5 Q9UQL6 3/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
MAPT P10636 2/20 0.33
LMNA P02545 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
ESR1 P03372 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5705546 0.99 CYP2C19 (0.36) CYP2C19HIF1AFFAR4TAAR1HDAC1
SCHEMBL6433146 0.94 FFAR4 (0.38) CYP2C19HIF1AFFAR4TAAR1HDAC1
SCHEMBL6430921 0.86 CNR2 (0.39) FFAR4MAPTTDP1CNR1CNR2
SCHEMBL10258149 0.80 CYP2C19 (0.37) CYP2C19HIF1AHDAC1HDAC3HDAC4
SCHEMBL6180751 0.78 CYP2C19 (0.38) CYP2C19HIF1AHDAC1HDAC3HDAC4
SCHEMBL10259191 0.78 CYP2C19 (0.38) CYP2C19HIF1AMAPTLMNAESR1
SCHEMBL6180234 0.78 CYP2C19 (0.38) CYP2C19HIF1AHDAC1HDAC3HDAC4
SCHEMBL5705302 0.77 FFAR4 (0.33) CYP2C19HIF1AFFAR4TAAR1CNR1
SCHEMBL10258797 0.77 CYP2C19 (0.37) CYP2C19HIF1AMAPTLMNATDP1
SCHEMBL17267375 0.77 CYP2C19 (0.48) CYP2C19HIF1AFFAR4TAAR1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1326822-A2 KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES Esperion Therapeutics Inc. (US) 2003-07-16 EP claimed
WO-2002030860-A2 KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES ESPERION THERAPEUTICS, INC. (US) 2002-04-18 WO claimed
EP-1701931-A1 KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES Esperion Therapeutics, Inc. (US) 2006-09-20 EP disclosed
WO-2005068412-A1 KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES ESPERION THERAPEUTICS, INC. (US) 2005-07-28 WO disclosed
EP-1326822-A2 KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES Esperion Therapeutics Inc. (US) 2003-07-16 EP disclosed
WO-2002030860-A9 KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES ESPERION THERAPEUTICS INC (US) 2003-02-20 WO disclosed
WO-2002030860-A2 KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES ESPERION THERAPEUTICS, INC. (US) 2002-04-18 WO disclosed