⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791433 | 0.74 | KDM4E (0.36) | — | |
| SCHEMBL2791430 | 0.74 | KDM4E (0.36) | — | |
| SCHEMBL1187503 | 0.71 | — | — | |
| SCHEMBL110898 | 0.69 | — | — | |
| SCHEMBL10399715 | 0.69 | — | — | |
| SCHEMBL92901 | 0.69 | — | — | |
| SCHEMBL5753306 | 0.69 | — | — | |
| SCHEMBL16416853 | 0.69 | — | — | |
| SCHEMBL92928 | 0.67 | — | — | |
| SCHEMBL1484545 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12145923-B2 | Tetrahydroisoquinoline compound, preparation method therefor, pharmaceutical composition containing same, and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2024-11-19 | — | — | US | claimed |
| CN-118851979-A | Preparation method of apremilast | 潍坊市海欣药业有限公司 | 2024-10-29 | — | — | CN | claimed |
| CN-115894310-A | Novel preparation method of apremilast chiral amine intermediate | 江苏正大清江制药有限公司 | 2023-04-04 | — | — | CN | claimed |
| EP-3856342-A1 | BICYCLIC DERIVATIVES AS GABAA A5 RECEPTOR MODULATORS | Richter Gedeon Nyrt. (HU) | 2021-08-04 | — | — | EP | claimed |
| WO-2020065597-A1 | BICYCLIC DERIVATIVES AS GABAA Α5 RECEPTOR MODULATORS | RICHTER GEDEON NYRT. (HU) | 2020-04-02 | — | — | WO | claimed |
| EP-2683723-A1 | SPIROCYCLIC ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | Zoetis LLC (US) | 2014-01-15 | — | — | EP | claimed |
| WO-2012120399-A1 | SPIROCYCLIC ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | PFIZER INC. (US) | 2012-09-13 | — | — | WO | claimed |
| US-20100278767-A1 | Lightening Agents and/or Dyes that Contain Aldehyde(s) | HENKEL AG & CO. KGAA (DE) | 2010-11-04 | — | — | US | claimed |
| EP-2051689-A1 | LIGHTENING AGENTS AND/OR DYES THAT CONTAIN ALDEHYDE(S) | Henkel AG & Co. KGaA (DE) | 2009-04-29 | — | — | EP | claimed |
| EP-2041139-A2 | PHARMACEUTICAL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-04-01 | — | — | EP | claimed |
| WO-2008019986-A1 | LIGHTENING AGENTS AND/OR DYES THAT CONTAIN ALDEHYDE(S) | HENKEL AG & CO. KGAA (DE) | 2008-02-21 | — | — | WO | claimed |
| WO-2007127175-A2 | PHARMACEUTICAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-11-08 | — | — | WO | claimed |
| US-20060094710-A1 | Piperidine-pyridazones and phthalazones as pde4 inhibitors | ALTANA PHARMA AG (DE) | 2006-05-04 | — | — | US | claimed |
| EP-1556049-A1 | PIPERIDINE-PYRIDAZONES AND PHTHALAZONES AS PDE4 INHIBITORS | ALTANA Pharma AG (DE) | 2005-07-27 | — | — | EP | claimed |
| WO-2004017974-A1 | PIPERIDINE-PYRIDAZONES AND PHTHALAZONES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | WO | claimed |
| WO-2026087677-A1 | ENANTIOSELECTIVE SYNTHESIS OF (S)-AFOXOLANER AND SOLID FORMS OF (S)-AFOXOLANER | KRKA, D.D., NOVO MESTO (SI) | 2026-04-30 | — | — | WO | disclosed |
| EP-4580627-A1 | TREATMENT OF FASCIOLOSIS | Intervet International B.V. (NL) | 2025-07-09 | — | — | EP | disclosed |
| EP-1481972-A1 | CYCLIC COMPOUND, PROCESS FOR PRODUCING THE SAME, AND PEST CONTROL AGENT | Sumitomo Chemical Takeda Agro Company, Limited (JP) | 2004-12-01 | — | — | EP | disclosed |
| WO-2004017974-A1 | PIPERIDINE-PYRIDAZONES AND PHTHALAZONES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | WO | disclosed |
| US-4355184-A | BY REACTING AN ALDEHYDE WITH AN ALKALI METAL SALT OF ACETOACETIC | NIPPON SODA COMPANY LIMITED (JP) | 1982-10-19 | — | — | US | disclosed |