⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17225086 | 0.97 | PDE10A (0.42) | — | |
| Hydrochloric Acid SCHEMBL28073257 | 0.97 | PDE10A (0.42) | — | |
| Ammonia Solution, Strong SCHEMBL9197440 | 0.97 | PDE10A (0.42) | — | |
| Fluoride SCHEMBL27905674 | 0.97 | POLB (0.45) | — | |
| Hydrochloric Acid SCHEMBL29730080 | 0.97 | PDE10A (0.42) | — | |
| Ammonia Solution, Strong SCHEMBL28235751 | 0.95 | PDE10A (0.41) | — | |
| Carbamic Acid SCHEMBL1413206 | 0.86 | NAPRT (0.44) | — | |
| SCHEMBL448240 | 0.72 | — | — | |
| SCHEMBL3293002 | 0.71 | PDE10A (0.36) | — | |
| SCHEMBL446354 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1565 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118852028-A | Nitrone pyrimidine ring compound and preparation method thereof | 南京工业大学 | 2024-10-29 | — | — | CN | claimed |
| EP-3131914-B1 | 3'-SUBSTITUTED METHYL OR ALKYNYL NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS LLC (US) | 2023-05-10 | — | — | EP | claimed |
| CN-114250480-A | Reduction method of nitroso-nitro pyrimidine compound | 成都化润药业有限公司 | 2022-03-29 | — | — | CN | claimed |
| EP-2480330-B1 | A PROCESS AND CATALYST FOR THE CATALYTIC HYDROGENATION OF AROMATIC AND HETEROAROMATIC NITRO COMPOUNDS | ASTRAZENECA AB (SE) | 2021-05-26 | — | — | EP | claimed |
| CN-211885477-U | Rotary dryer is used in production of 24 dichloro 5 nitropyrimidines | 南京麦瑞米生物技术有限公司 | 2020-11-10 | — | — | CN | claimed |
| CN-211885469-U | 24 dichloro 5 nitropyrimidine crystallization equipment | 南京麦瑞米生物技术有限公司 | 2020-11-10 | — | — | CN | claimed |
| US-10202411-B2 | 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV | IDENIX PHARMACEUTICALS LLC (US) | 2019-02-12 | — | — | US | claimed |
| US-20180162898-A1 | 4'-OR NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS LLC (US) | 2018-06-14 | — | — | US | claimed |
| CN-107903215-A | A kind of preparation method and applications of 2,4 diaminourea, 5 nitro, 6 hydroxy pyrimidine | 潍坊奥通药业有限公司 | 2018-04-13 | — | — | CN | claimed |
| CN-106749039-A | A kind of preparation method of 2 nitro-pyrimidine derivative | 湖南华腾制药有限公司 | 2017-05-31 | — | — | CN | claimed |
| WO-2004028445-A2 | PROCESSES FOR PREPARING 1,3-DIOXOLANE NUCLEOSIDES | PHARMASSET INC. (US) | 2004-04-08 | — | — | WO | claimed |
| US-20030135048-A1 | Stereoselective methods for the preparation of nucleosides | SHIRE BIOCHEM INC. (CA) | 2003-07-17 | — | — | US | claimed |
| US-6518425-B1 | A process for producing a 1,3-oxathiolane nucleoside comprising reacting a 5-halo-2-protected-oxymethyl-1,3-oxathiolane with a silylated purine or pyrimidine without the addition of a Lewis acid or an additional base to the reaction | EMORY UNIVERSITY | 2003-02-11 | — | — | US | claimed |
| US-20030013880-A1 | Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers | APOTEX PHARMACHEM INC (CA) | 2003-01-16 | — | — | US | claimed |
| WO-2002102796-A1 | STEREOSELECTIVE METHOD FOR THE PREPARATION OF NUCLEOSIDE ANALOGUES | SHIRE BIOCHEM INC. (CA) | 2002-12-27 | — | — | WO | claimed |
| EP-0885225-B1 | TETRAHYDROPYRIMIDINE DERIVATIVES | BAYER AG (DE) | 2002-01-23 | — | — | EP | claimed |
| CN-1212697-A | Tetrahydropyrimidine derivatives | BAYER AG (DE) | 1999-03-31 | — | — | CN | claimed |
| US-4055411-A | 5-NITRO-PYRIMIDINES | CIBA-GEIGY CORPORATION (US) | 1977-10-25 | — | — | US | claimed |
| US-3948883-A | Synthesis of purine nucleosides | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1976-04-06 | — | — | US | claimed |
| US-3948914-A | PLANT GROWTH REGULATORS | CIBA-GEIGY CORPORATION (US) | 1976-04-06 | — | — | US | claimed |