Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3771623 | 0.88 | NTRK1 (0.50) | NTRK1JAK2JAK3 | |
| SCHEMBL3257549 | 0.88 | NTRK1 (0.56) | NTRK1JAK2JAK3MKNK1MKNK2 | |
| SCHEMBL3775597 | 0.87 | JAK2 (0.48) | NTRK1JAK2JAK3 | |
| SCHEMBL4073888 | 0.84 | NTRK1 (0.53) | NTRK1JAK2JAK3MKNK1MKNK2 | |
| SCHEMBL27658319 | 0.78 | NTRK1 (0.49) | NTRK1JAK2JAK3MKNK1MKNK2 | |
| SCHEMBL2568432 | 0.77 | NTRK1 (0.55) | NTRK1JAK2JAK3MKNK1MKNK2 | |
| SCHEMBL3012762 | 0.76 | NTRK1 (0.50) | NTRK1JAK2JAK3 | |
| SCHEMBL4162039 | 0.76 | NTRK1 (0.62) | NTRK1JAK2JAK3 | |
| SCHEMBL2571347 | 0.74 | HTT (0.46) | NTRK1MKNK1MKNK2MAPK1 | |
| SCHEMBL3341203 | 0.73 | NTRK1 (0.51) | NTRK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383268-A1 | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | AstraZeneca AB (SE) | 2011-11-02 | — | — | EP | disclosed |