Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 19/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4915059 | 0.92 | CSF1R (0.57) | CSF1REGFRERBB2 | |
| SCHEMBL4914194 | 0.92 | CSF1R (0.50) | CSF1REGFRERBB2 | |
| SCHEMBL4912938 | 0.89 | CSF1R (0.52) | CSF1REGFRERBB2 | |
| SCHEMBL4910737 | 0.89 | CSF1R (0.55) | CSF1R | |
| SCHEMBL4909536 | 0.88 | CSF1R (0.51) | CSF1R | |
| SCHEMBL4905694 | 0.87 | CSF1R (0.51) | CSF1REGFRERBB2 | |
| SCHEMBL27662886 | 0.87 | KCNH2 (0.49) | CSF1R | |
| SCHEMBL4905028 | 0.84 | CSF1R (0.54) | CSF1R | |
| SCHEMBL4916770 | 0.84 | CSF1R (0.48) | CSF1R | |
| SCHEMBL4911139 | 0.84 | CSF1R (0.56) | CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718615-A1 | NOVEL QUINOLINE-CARBAXAMIDES AS JACK3 KINASE MODULATORS | AstraZeneca AB (SE) | 2006-11-08 | — | — | EP | claimed |
| WO-2005075429-A1 | NOVEL QUINOLINE-CARBAXAMIDES AS JACK3 KINASE MODULATORS | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | claimed |