Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 5/20 | 0.40 |
| ▸ | HPD | P32754 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | SOD1 | P00441 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5708215 | 0.92 | GRM5 (0.40) | GRM5MAOBHPDFFAR1FFAR4 | |
| SCHEMBL5708162 | 0.88 | MAOB (0.46) | GRM5MAOBHPDNPC1ALDH1A1 | |
| SCHEMBL3918694 | 0.87 | FFAR1 (0.47) | MAOBFFAR1FFAR4ALDH1A1SMN1; SMN2 | |
| SCHEMBL5708219 | 0.80 | MAOB (0.44) | GRM5MAOBHPDNPC1ALDH1A1 | |
| SCHEMBL5708160 | 0.77 | MRGPRX4 (0.49) | MAOBFFAR1FFAR4NPC1ALDH1A1 | |
| SCHEMBL3920926 | 0.76 | FFAR1 (0.45) | MAOBFFAR1FFAR4APP | |
| SCHEMBL20404210 | 0.76 | FFAR1 (0.47) | MAOBFFAR1FFAR4SMN1; SMN2L3MBTL1 | |
| SCHEMBL3918662 | 0.74 | MAOB (0.48) | MAOBFFAR1FFAR4TP53SMN1; SMN2 | |
| SCHEMBL29925382 | 0.73 | MAOB (0.54) | MAOBGSTP1MAOAL3MBTL1 | |
| SCHEMBL2133357 | 0.73 | MAOB (0.54) | MAOBGSTP1MAOAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706386-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066136-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |