Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 13/20 | 0.44 |
| ▸ | PPARA | Q07869 | 8/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965601 | 0.90 | PPARD (0.46) | PPARDPPARAPPARGPARP1ADORA3 | |
| SCHEMBL4460350 | 0.87 | PPARD (0.46) | PPARDPPARAPPARG | |
| SCHEMBL4460354 | 0.87 | PPARD (0.46) | PPARDPPARAPPARG | |
| SCHEMBL3969637 | 0.86 | PPARA (0.49) | PPARDPPARAPPARGPARP1ADORA3 | |
| SCHEMBL5708179 | 0.84 | PPARD (0.46) | PPARDPPARAPPARGPARP1ADORA3 | |
| SCHEMBL3962077 | 0.83 | PPARD (0.47) | PPARDPPARAPPARGPARP1ADORA3 | |
| SCHEMBL5708221 | 0.80 | PPARD (0.40) | PPARDPPARAPPARGPARP1 | |
| SCHEMBL4479616 | 0.79 | PPARD (0.47) | PPARDPPARAPPARGAKR1B1PTGES | |
| SCHEMBL3966176 | 0.78 | PPARA (0.51) | PPARDPPARAPPARGADORA3AKR1B1 | |
| SCHEMBL13865163 | 0.77 | PPARD (0.48) | PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706386-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-10-04 | — | — | EP | claimed |
| WO-2005066136-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | claimed |
| EP-1706386-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066136-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |