⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Fluorofucose SCHEMBL8578272 | 1.00 | — | — | |
| 2-Fluorofucose SCHEMBL20560114 | 1.00 | — | — | |
| 2-Fluorofucose SCHEMBL29709536 | 1.00 | — | — | |
| 2-Fluorofucose SCHEMBL570815 | 0.93 | TP53 (0.32) | — | |
| 2-Fluorofucose SCHEMBL31427535 | 0.93 | TP53 (0.32) | — | |
| SCHEMBL12561411 | 0.73 | PTPN1 (0.36) | — | |
| L-Fucose SCHEMBL466429 | 0.72 | — | — | |
| L-Fucose SCHEMBL11347428 | 0.72 | — | — | |
| L-Fucose SCHEMBL16703726 | 0.72 | — | — | |
| L-Fucose SCHEMBL5072536 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250114386-A1 | COMBINATION OF A GLYCOSYLATION INHIBITOR WITH ONE CAR CELL THERAPY FOR TREATING CANCER | OSPEDALE SAN RAFFAELE S.R.L. (IT) | 2025-04-10 | — | — | US | claimed |
| EP-2282773-B2 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEAGEN INC (US) | 2025-03-05 | — | — | EP | claimed |
| US-20230038373-A1 | STABILE CONJUGATE | GLYKOS BIOMEDICAL OY (FI) | 2023-02-09 | — | — | US | claimed |
| US-11319526-B2 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation | SEAGEN INC. (US) | 2022-05-03 | — | — | US | claimed |
| US-20210402002-A1 | CONJUGATE | GLYKOS BIOMEDICAL OY (FI) | 2021-12-30 | — | — | US | claimed |
| US-20210290646-A1 | COMBINATION OF A GLYCOSYLATION INHIBITOR WITH ONE CAR CELL THERAPY FOR TREATING CANCER | OSPEDALE SAN RAFFAELE S.R.L. (IT) | 2021-09-23 | — | — | US | claimed |
| WO-2021123506-A1 | STABILE CONJUGATE | GLYKOS BIOMEDICAL OY (FI) | 2021-06-24 | — | — | WO | claimed |
| US-11033561-B2 | Methods of inhibition of protein fucosylation in vivo using fucose analogs | SEAGEN INC. (US) | 2021-06-15 | — | — | US | claimed |
| CN-112969712-A | Combination of glycosylation inhibitors with CAR cell therapy for the treatment of cancer | 圣拉斐尔医院有限公司 | 2021-06-15 | — | — | CN | claimed |
| EP-3827017-A1 | COMBINATION OF A GLYCOSYLATION INHIBITOR WITH ONE CAR CELL THERAPY FOR TREATING CANCER | Ospedale San Raffaele S.r.l. (IT) | 2021-06-02 | — | — | EP | claimed |
| EP-2608796-B1 | INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS | SEATTLE GENETICS INC (US) | 2018-11-21 | — | — | EP | claimed |
| US-20180155677-A1 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEAGEN INC. | 2018-06-07 | — | — | US | claimed |
| US-20170035790-A1 | METHODS OF INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS | SEATTLE GENETICS, INC. (US) | 2017-02-09 | — | — | US | claimed |
| EP-2282773-B1 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEATTLE GENETICS INC (US) | 2014-01-15 | — | — | EP | claimed |
| US-8574907-B2 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation | SEATTLE GENETICS, INC. (US) | 2013-11-05 | — | — | US | claimed |
| US-20120183997-A1 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEATTLE GENETICS, INC. (US) | 2012-07-19 | — | — | US | claimed |
| US-8163551-B2 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation | SEATTLE GENETICS, INC. (US) | 2012-04-24 | — | — | US | claimed |
| JP-2011519567-A | — | — | 2011-07-14 | — | — | JP | claimed |
| EP-2282773-A2 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | Seattle Genetics, Inc. (US) | 2011-02-16 | — | — | EP | claimed |
| WO-2009135181-A2 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEATTLE GENETICS, INC. (US) | 2009-11-05 | — | — | WO | claimed |