Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3833863 | 0.97 | NR1H4 (0.43) | NR1H4ELANECTSDKDM4EALDH1A1 | |
| SCHEMBL4598864 | 0.96 | NR1H4 (0.47) | NR1H4ELANEKDM4EALDH1A1 | |
| SCHEMBL5690082 | 0.94 | NR1H4 (0.48) | NR1H4CTSDKDM4EALDH1A1 | |
| SCHEMBL4624338 | 0.92 | NR1H4 (0.40) | NR1H4ELANECTSD | |
| SCHEMBL5721660 | 0.92 | NR1H4 (0.45) | NR1H4ELANECTSDKDM4EALDH1A1 | |
| SCHEMBL3835251 | 0.91 | NR1H4 (0.44) | NR1H4ELANECTSDKDM4EALDH1A1 | |
| SCHEMBL5689568 | 0.90 | NR1H4 (0.42) | NR1H4ELANECTSDKDM4EALDH1A1 | |
| SCHEMBL5689217 | 0.90 | NR1H4 (0.38) | NR1H4 | |
| SCHEMBL4598886 | 0.89 | NR1H4 (0.43) | NR1H4ELANECTSD | |
| SCHEMBL3836167 | 0.89 | NR1H4 (0.45) | NR1H4ELANECTSDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699759-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061452-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |