Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.48 |
| ▸ | ACE | P12821 | 3/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283214 | 1.00 | MME (0.48) | MMEACEP2RX1P2RX3P2RX4 | |
| Hydrochloric Acid SCHEMBL5712964 | 0.99 | MME (0.48) | MMEACEP2RX1P2RX3P2RX4 | |
| Hydrochloric Acid SCHEMBL7279438 | 0.99 | MME (0.48) | MMEACEP2RX1P2RX3P2RX4 | |
| SCHEMBL2687108 | 0.83 | MME (0.55) | MMEACENPC1RAB9AALDH1A1 | |
| SCHEMBL200386 | 0.83 | MME (0.55) | MMEACENPC1RAB9AALDH1A1 | |
| SCHEMBL200387 | 0.83 | MME (0.55) | MMEACENPC1RAB9AALDH1A1 | |
| SCHEMBL7290163 | 0.81 | MAPT (0.43) | CCKBRSMN1; SMN2 | |
| SCHEMBL7290156 | 0.81 | MAPT (0.43) | CCKBRSMN1; SMN2 | |
| SCHEMBL17653866 | 0.80 | KMT2A (0.57) | TSHRALDH1A1LMNATP53 | |
| SCHEMBL7298515 | 0.79 | MME (0.51) | MMEACETSHRRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0135349-B1 | CONDENSED SEVEN-MEMBERED RING COMPOUNDS AND THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1988-11-02 | — | — | EP | claimed |
| EP-0135349-A1 | Condensed seven-membered ring compounds and their production and use | Takeda Chemical Industries, Ltd. (JP) | 1985-03-27 | — | — | EP | claimed |
| EP-0942925-B1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | VERTEX PHARMA (US) | 2006-11-22 | — | — | EP | disclosed |
| EP-1466921-A1 | Inhibitors of interleukin-1 beta converting enzyme | Vertex Pharmaceuticals Incorporated (US) | 2004-10-13 | — | — | EP | disclosed |
| US-6350741-B1 | 1-BENZAZEPINE DERIVATIVES; ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS; BONE AND AUTOIMMUNE DISORDER TREATMENT | VERTEX PHARMACEUTICAL, INC. | 2002-02-26 | — | — | US | disclosed |