Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5712917 | 0.90 | ADORA1 (0.70) | GAAPOLBADORA1MAPTMEN1 | |
| SCHEMBL5712814 | 0.88 | ADORA1 (0.61) | GAAPOLBADORA1MAPTMEN1 | |
| SCHEMBL5506528 | 0.83 | GAA (0.66) | GAAPOLBADORA1MAPTMEN1 | |
| SCHEMBL5712833 | 0.83 | ADORA1 (0.60) | GAAPOLBADORA1MAPTMEN1 | |
| SCHEMBL5712830 | 0.80 | GAA (0.59) | GAAPOLBADORA1MAPTMEN1 | |
| SCHEMBL7773976 | 0.78 | ADORA1 (0.73) | GAAPOLBADORA1MAPTMEN1 | |
| SCHEMBL5508041 | 0.78 | MEN1 (0.62) | GAAPOLBADORA1MAPTMEN1 | |
| SCHEMBL6993515 | 0.77 | GAA (1.00) | GAAPOLBADORA1MAPTMEN1 | |
| SCHEMBL5678867 | 0.75 | ADORA1 (0.71) | GAAPOLBADORA1MAPTMEN1 | |
| SCHEMBL5712840 | 0.74 | ADORA1 (0.76) | POLBADORA1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1671973-A2 | Allosteric adenosine receptor modulators | King Pharmaceuticals Research and Development, Inc. (US) | 2006-06-21 | — | — | EP | claimed |
| EP-1025106-A2 | ALLOSTERIC ADENOSINE RECEPTOR MODULATORS | Medco Research, Inc. (US) | 2000-08-09 | — | — | EP | claimed |
| WO-1999021617-A2 | ALLOSTERIC ADENOSINE RECEPTOR MODULATORS | MEDCO RESEARCH, INC. (US) | 1999-05-06 | — | — | WO | claimed |
| EP-1671973-A2 | Allosteric adenosine receptor modulators | King Pharmaceuticals Research and Development, Inc. (US) | 2006-06-21 | — | — | EP | disclosed |
| EP-1025106-B1 | ALLOSTERIC ADENOSINE RECEPTOR MODULATORS | KING PHARMACEUTICALS RES & DEV (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20040121406-A1 | Methods and formulations for increasing the affinity of a1 adenosine receptor ligands for the a1 adenosine receptor | ENDACEA, INC. | 2004-06-24 | — | — | US | disclosed |
| US-6323214-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS AND ANALGESICS | MEDCO RESEARCH, INC | 2001-11-27 | — | — | US | disclosed |
| US-6194449-B1 | ADMINISTERING A BENZOYLTHIOPHENE COMPOUND; ANTIHYPOXIC, ANTIISCHEMIC AGENTS | MEDCO CORP. | 2001-02-27 | — | — | US | disclosed |
| US-6177444-B1 | ANTIISCHEMIC AGENTS; ANTIARRHYTHMIA AGENTS | MEDCO CORP. | 2001-01-23 | — | — | US | disclosed |