Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1369991 | 1.00 | BTK (0.48) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL31601158 | 1.00 | BTK (0.48) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL30473209 | 0.91 | BTK (0.51) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL31601203 | 0.87 | BTK (0.37) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL15777845 | 0.82 | BTK (0.61) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL31601393 | 0.82 | KDM1A (0.40) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL31601395 | 0.82 | KDM1A (0.40) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL4479750 | 0.82 | BTK (0.39) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL30473133 | 0.82 | BTK (0.39) | BTKKDM1AGAAMAOBNFKB1 | |
| SCHEMBL4479752 | 0.82 | BTK (0.39) | BTKKDM1AGAAMAOBNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044498-A9 | ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS | ACHAOGEN, INC. (US) | 2012-02-09 | — | — | WO | disclosed |
| WO-2011044498-A1 | ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS | ACHAOGEN, INC. (US) | 2011-04-14 | — | — | WO | disclosed |
| WO-2010132839-A2 | AMINOGLYCOSIDE DOSING REGIMENS | ACHAOGEN, INC. (US) | 2010-11-18 | — | — | WO | disclosed |