Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL18421895 | 0.98 | TSHR (0.41) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| Acetic Acid SCHEMBL2857432 | 0.98 | TSHR (0.44) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| Ethylenediamine SCHEMBL1519546 | 0.96 | TSHR (0.46) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| Acetic Acid SCHEMBL2593860 | 0.86 | TSHR (0.55) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| Ethylamine SCHEMBL8850204 | 0.84 | TSHR (0.48) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| SCHEMBL28930565 | 0.83 | — | — | |
| Methylamine SCHEMBL9247975 | 0.81 | — | — | |
| SCHEMBL132424 | 0.81 | — | — | |
| Ammonia Solution, Strong SCHEMBL16209179 | 0.78 | — | — | |
| Acetic Acid SCHEMBL9956991 | 0.78 | FFAR3 (0.50) | TSHRGABRR1SMN1; SMN2BLMALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10306015-A | — | — | None | — | — | JP | disclosed |
| CN-114173758-B | Aqueous composition | 株式会社资生堂 | 2024-05-31 | — | — | CN | disclosed |
| CN-117940109-A | Composition for preventing bromhidrosis | 持田制药株式会社 | 2024-04-26 | — | — | CN | disclosed |
| EP-4356897-A1 | POWDER COSMETIC AND PRODUCTION METHOD FOR SAME | Shiseido Company, Ltd. (JP) | 2024-04-24 | — | — | EP | disclosed |
| CN-117915887-A | Cleaning agent | 株式会社资生堂 | 2024-04-19 | — | — | CN | disclosed |
| CN-115151239-B | Oil-in-water emulsion composition | 株式会社资生堂 | 2024-03-19 | — | — | CN | disclosed |
| CN-113599346-B | Skin care and repair composition | 浙江楚沅生物科技有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-117460490-A | Skin external composition containing taurine crystal with useful component | 考司美德制药株式会社 | 2024-01-26 | — | — | CN | disclosed |
| CN-117377454-A | Skin care composition | 考司美德制药株式会社 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023219108-A1 | OIL-IN-WATER COMPOSITION | 株式会社 資生堂 | 2023-11-16 | — | — | WO | disclosed |
| WO-2005102267-A1 | AGENT FOR SKIN EXTERNAL USE CONTAINING TOCOPHEROL DERIVATIVE, ASCORBIC ACID DERIVATIVE AND SURFACE ACTIVE AGENT HAVING LIPOPEPTIDE STRUCTURE | SHOWA DENKO K.K. (JP) | 2005-11-03 | — | — | WO | disclosed |
| WO-2005094777-A1 | EXTERNAL PREPARATION FOR SKIN | SHOWA DENKO K.K. (JP) | 2005-10-13 | — | — | WO | disclosed |
| US-20050220744-A1 | Polysaccharide/functional compound complex | SHOWA DENKO K.K. | 2005-10-06 | — | — | US | disclosed |
| WO-2005089708-A1 | OIL-IN-WATER EMULSIFIED COMPOSITION, AND EXTERNAL PREPARATION FOR SKIN AND COSMETICS USING THE COMPOSITION | SHOWA DENKO K.K. (JP) | 2005-09-29 | — | — | WO | disclosed |
| WO-2005020950-A1 | COSMETIC COMPOSITION COMPRISING A AND A LIPOPEPTIDE | SHOWA DENKO K.K. (JP) | 2005-03-10 | — | — | WO | disclosed |
| EP-1430905-A1 | EXTERNAL PREPARATION FOR THE SKIN | SHISEIDO COMPANY LIMITED (JP) | 2004-06-23 | — | — | EP | disclosed |
| US-20030003071-A1 | Hair growth stimulant | SHISEIDO COMPANY, LTD. (JP) | 2003-01-02 | — | — | US | disclosed |
| EP-1234574-A1 | HAIR GROWTH STIMULANT | SHISEIDO COMPANY LIMITED (JP) | 2002-08-28 | — | — | EP | disclosed |
| EP-1153602-A1 | SKIN PREPARATIONS FOR EXTERNAL USE | SHISEIDO COMPANY LIMITED (JP) | 2001-11-14 | — | — | EP | disclosed |
| JP-H10306015-A | MAKE-UP COSMETIC | SHISEIDO CO LTD | 1998-11-17 | — | — | JP | disclosed |