Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MPO | P05164 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | APAF1 | O14727 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL578606 | 0.86 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL30912052 | 0.86 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL891879 | 0.86 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL1362995 | 0.86 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL29361050 | 0.86 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL29556806 | 0.86 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8742447 | 0.85 | SMN1; SMN2 (0.62) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8403647 | 0.84 | KDM4E (0.78) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL29865910 | 0.84 | KDM4E (0.78) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL617181 | 0.84 | KDM4E (0.78) | SMN1; SMN2MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363925-B1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |
| US-20060211636-A1 | Macrolide Antibiotics | ALIHODZIC SULEJMAN | 2006-09-21 | — | — | US | disclosed |
| US-20050215495-A1 | Macrolide antibiotics | ALIHODZIC SULEJMAN | 2005-09-29 | — | — | US | disclosed |
| US-20040077557-A1 | Macrolide antibiotics | GLAXO GROUP LIMITED (GB) | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215495-A1 | Macrolide antibiotics | IL1R1, MRPL12, RPS21 | SMN1; SMN2 3554/4885MAPT 3557/4885KDM4E 1204/4885 |
| US-20060211636-A1 | Macrolide Antibiotics | IL1R1, MRPL12, RPS21 | SMN1; SMN2 3554/4885MAPT 3557/4885KDM4E 1204/4885 |
| US-20040077557-A1 | Macrolide antibiotics | MALT1, MRPL21, IL1R1 | SMN1; SMN2 3041/4885MAPT 3349/4885KDM4E 1358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.