Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 14/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | PKLR | P30613 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27656001 | 1.00 | SLC6A2 (0.52) | SLC6A2SLC6A4NOTUMFFAR4SLC6A7 | |
| SCHEMBL28763192 | 1.00 | SLC6A2 (0.52) | SLC6A2SLC6A4NOTUMFFAR4SLC6A7 | |
| SCHEMBL3950214 | 0.89 | SLC6A2 (0.52) | SLC6A2SLC6A4 | |
| SCHEMBL3953918 | 0.88 | SLC6A2 (0.50) | SLC6A2SLC6A4 | |
| SCHEMBL3954276 | 0.88 | SLC6A2 (0.50) | SLC6A2SLC6A4 | |
| SCHEMBL3953408 | 0.88 | SLC6A2 (0.51) | SLC6A2SLC6A4NOTUMFFAR4HSD11B1 | |
| SCHEMBL3952934 | 0.87 | SLC6A2 (0.53) | SLC6A2SLC6A4 | |
| SCHEMBL3956503 | 0.87 | SLC6A2 (0.53) | SLC6A2SLC6A4 | |
| SCHEMBL3954680 | 0.87 | SLC6A2 (0.53) | SLC6A2SLC6A4 | |
| SCHEMBL27662478 | 0.87 | SLC6A2 (0.49) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1972920-A | Arylalkyl piperazine derivatives for the treatment of conditions ameliorated by monoamine reuptake including vasomotor symptoms | WYETH CORP (US) | 2007-05-30 | — | — | CN | disclosed |
| CN-1894226-A | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use | WYETH CORP (US) | 2007-01-10 | — | — | CN | disclosed |
| EP-1687288-A1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2006-08-09 | — | — | EP | disclosed |
| EP-1673059-A2 | ALKANOL AND CYCLOALKANOL-AMINE DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005037207-A2 | ARYLALKYL-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF CONDITIONS AMELIORATED BY MONOAMINE REUPTAKE INCLUDING VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |
| WO-2005037809-A1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |