Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5720652 | 0.89 | MAPT (0.45) | MAPTTP53POLBCHEK1ALDH1A1 | |
| SCHEMBL425747 | 0.82 | MAPT (0.52) | MAPTTP53POLBCHEK1ALDH1A1 | |
| SCHEMBL3326864 | 0.81 | MAPT (0.61) | MAPTTP53POLBCHEK1ALDH1A1 | |
| SCHEMBL3326035 | 0.80 | MAPT (0.52) | MAPTTP53POLBCHEK1ALDH1A1 | |
| SCHEMBL427561 | 0.80 | GBA1 (0.49) | MAPTTP53POLBCHEK1ALDH1A1 | |
| SCHEMBL5720646 | 0.79 | CHEK1 (0.48) | MAPTTP53POLBCHEK1ALDH1A1 | |
| SCHEMBL430842 | 0.79 | GBA1 (0.65) | MAPTTP53POLBCHEK1ALDH1A1 | |
| SCHEMBL426750 | 0.78 | CHEK1 (0.55) | MAPTTP53POLBCHEK1ALDH1A1 | |
| SCHEMBL3325223 | 0.78 | SLC29A1 (0.52) | MAPTTP53POLBCHEK1ALDH1A1 | |
| SCHEMBL10198825 | 0.78 | CHEK1 (0.50) | MAPTTP53POLBCHEK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626725-A2 | HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS | Synta Pharmaceuticals Corporation (US) | 2006-02-22 | — | — | EP | disclosed |
| WO-2005000404-A2 | HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS | SYNTA PHARMACEUTICALS, CORP. (US) | 2005-01-06 | — | — | WO | disclosed |