SCHEMBL5721697

SCHEMBL5721697

CCCOC(=O)N1C=Cc2ccccc2C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.41
LMNA P02545 3/20 0.40
HDAC3 O15379 1/20 0.39
ADORA3 P0DMS8 1/20 0.36
ADORA1 P30542 1/20 0.36
HSD17B3 P37058 1/20 0.36
NAMPT P43490 2/20 0.35
TSHR P16473 2/20 0.35
TP53 P04637 1/20 0.35
CYP3A4 P08684 1/20 0.35
MAPK1 P28482 1/20 0.35
BCHE P06276 1/20 0.35
CHRM2 P08172 1/20 0.34
CHRM4 P08173 1/20 0.34
CHRM5 P08912 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
GAA P10253 1/20 0.34
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL324190 0.92 BCHE (0.44) ALDH1A1LMNAHDAC3NAMPTTSHR
SCHEMBL15056964 0.90 HDAC3 (0.41) ALDH1A1LMNAHDAC3HSD17B3NAMPT
SCHEMBL29493251 0.90 HDAC3 (0.41) ALDH1A1LMNAHDAC3HSD17B3NAMPT
SCHEMBL323769 0.88 TSHR (0.42) ALDH1A1HDAC3HSD17B3NAMPTTSHR
SCHEMBL15056529 0.85 P2RX4 (0.39) LMNAHDAC3HSD17B3NAMPTMAPK1
SCHEMBL15056629 0.85 HDAC3 (0.39) ALDH1A1HDAC3HSD17B3P2RX4
SCHEMBL15056675 0.84 HDAC3 (0.36) ALDH1A1HDAC3HSD17B3NAMPTMAPK1
SCHEMBL323621 0.84 P2RX4 (0.44) ALDH1A1LMNAHDAC3ADORA3NAMPT
SCHEMBL15056783 0.83 MEN1 (0.41) HDAC3HSD17B3
SCHEMBL15056981 0.82 HDAC3 (0.35) HDAC3HSD17B3NAMPTP2RX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103787969-B A kind of (1S)-1-phenyl-3,4-dihydro-2(1H) preparation method of-isoquinolinecarboxylic acid ester 上海京新生物医药有限公司 2016-07-06 CN disclosed
EP-1687299-A1 HETEROCYCLIC COMPOUNDS AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS, USEFUL FOR THE TREAMTMENT AND/OR PREVENTION OF DISORDERS MODULATED BY A PPAR ELI LILLY AND COMPANY (US) 2006-08-09 EP disclosed
WO-2005051945-A1 HETEROCYCLIC COMPOUNDS AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS, USEFUL FOR THE TREATMENT AND/OR PREVENTION OF DISORDERS MODULATED BY A PPAR ELI LILLY AND COMPANY (US) 2005-06-09 WO disclosed