Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 10/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5722946 | 0.99 | CYP19A1 (0.42) | CYP19A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5722734 | 0.99 | PDE4A (0.43) | CYP19A1PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL5723210 | 0.98 | PDE4A (0.43) | CYP19A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5723450 | 0.92 | HSP90AA1 (0.44) | CYP19A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5723309 | 0.92 | PDE4A (0.41) | CYP19A1PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL5723081 | 0.91 | HSP90AA1 (0.43) | CYP19A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5722981 | 0.90 | HSP90AA1 (0.45) | CYP19A1PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL5723001 | 0.89 | HSP90AA1 (0.44) | CYP19A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5723155 | 0.84 | HSP90AA1 (0.44) | CYP19A1PDE4APDE4BHSP90AA1LMNA | |
| SCHEMBL5723055 | 0.84 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771794-B1 | OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-05-03 | — | — | EP | disclosed |
| US-6716987-B1 | PHOSPHODIESTERASE IV INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |
| US-6514996-B2 | Derivatives of benzofuran or benzodioxole | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-02-04 | — | — | US | disclosed |
| EP-0771794-A1 | OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-05-07 | — | — | EP | disclosed |