Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 16/20 | 0.58 |
| ▸ | PPARG | P37231 | 11/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726047 | 0.92 | FFAR1 (0.55) | PPARAPPARGFFAR1 | |
| SCHEMBL5724659 | 0.92 | PPARA (0.57) | PPARAPPARGFFAR1 | |
| SCHEMBL4452526 | 0.91 | PPARA (0.57) | PPARAPPARGFFAR1LMNA | |
| SCHEMBL27486055 | 0.88 | PPARA (0.47) | PPARAPPARGFFAR1 | |
| SCHEMBL5724748 | 0.83 | PPARA (0.42) | PPARAPPARGFFAR1LMNAKMT2A | |
| SCHEMBL4450804 | 0.82 | PPARA (0.55) | PPARAPPARGFFAR1 | |
| SCHEMBL5726841 | 0.82 | FFAR1 (0.59) | PPARAPPARGFFAR1 | |
| SCHEMBL4834937 | 0.80 | HPGD (0.44) | PPARAPPARGFFAR1LMNAGAA | |
| SCHEMBL14106685 | 0.80 | HPGD (0.44) | PPARAPPARGFFAR1LMNAGAA | |
| SCHEMBL6487462 | 0.79 | PPARA (0.41) | PPARAPPARGFFAR1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177176-B1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA GMBH (DE) | 2006-04-19 | — | — | EP | disclosed |
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |