Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.46 |
| ▸ | CCND2 | P30279 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726016 | 1.00 | CDK2 (0.49) | CDK2CCNE1CCNE2CDK1CDK4 | |
| Iodide SCHEMBL5726329 | 0.99 | CDK2 (0.48) | CDK2CCNE1CCNE2CDK1CDK4 | |
| Iodide SCHEMBL5726335 | 0.99 | CDK2 (0.48) | CDK2CCNE1CCNE2CDK1CDK4 | |
| SCHEMBL5724827 | 0.92 | CDK2 (0.47) | CDK2CCNE1CCNE2CDK1CDK4 | |
| SCHEMBL5725166 | 0.89 | CDK2 (0.60) | CDK2CCNE1CCNE2CDK1CDK4 | |
| SCHEMBL5725172 | 0.89 | CDK2 (0.60) | CDK2CCNE1CCNE2CDK1CDK4 | |
| SCHEMBL5725687 | 0.89 | CDK2 (0.60) | CDK2CCNE1CCNE2CDK1CDK4 | |
| SCHEMBL5725069 | 0.86 | CDK2 (0.62) | CDK2CCNE1CCNE2CDK1CDK4 | |
| SCHEMBL5725059 | 0.86 | CDK2 (0.62) | CDK2CCNE1CCNE2CDK1CDK4 | |
| SCHEMBL5725374 | 0.86 | CDK2 (0.62) | CDK2CCNE1CCNE2CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087951-B9 | CARBON SUBSTITUTED AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-09-13 | — | — | EP | claimed |
| EP-1087951-B1 | CARBON SUBSTITUTED AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2005-02-09 | — | — | EP | claimed |