Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.53 |
| ▸ | CDK7 | P50613 | 6/20 | 0.53 |
| ▸ | CDK9 | P50750 | 6/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 3/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726709 | 1.00 | CDK2 (0.53) | CDK2CDK7CDK9CCNE1CCNE2 | |
| SCHEMBL5725346 | 0.89 | CDK2 (0.53) | CDK2CDK7CDK9CCNE1CCNE2 | |
| SCHEMBL5725355 | 0.89 | CDK2 (0.53) | CDK2CDK7CDK9CCNE1CCNE2 | |
| SCHEMBL5724972 | 0.88 | CDK2 (0.52) | CDK2CDK7CDK9CCNE1CCNE2 | |
| SCHEMBL5724979 | 0.88 | CDK2 (0.52) | CDK2CDK7CDK9CCNE1CCNE2 | |
| SCHEMBL5726308 | 0.87 | CDK2 (0.50) | CDK2CDK7CDK9CCNE1CCNE2 | |
| SCHEMBL5726298 | 0.87 | CDK2 (0.50) | CDK2CDK7CDK9CCNE1CCNE2 | |
| SCHEMBL5725385 | 0.86 | CDK2 (0.49) | CDK2CDK7CDK9CCNE1CCNE2 | |
| SCHEMBL5725377 | 0.86 | CDK2 (0.49) | CDK2CDK7CDK9CCNE1CCNE2 | |
| SCHEMBL5725342 | 0.84 | CDK2 (0.46) | CDK2CDK7CDK9CCNE1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087951-B9 | CARBON SUBSTITUTED AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-09-13 | — | — | EP | claimed |
| EP-1087951-B1 | CARBON SUBSTITUTED AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2005-02-09 | — | — | EP | claimed |