Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 12/20 | 0.53 |
| ▸ | FNTB | P49356 | 12/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.53 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8283305 | 0.88 | FNTA (0.51) | FNTAFNTBGRIA2GRIA4ALDH1A1 | |
| SCHEMBL3135478 | 0.87 | FNTA (0.69) | FNTAFNTBGRIA2GRIA4ALDH1A1 | |
| SCHEMBL3129020 | 0.86 | FNTA (0.55) | FNTAFNTBGRIA2GRIA4ALDH1A1 | |
| SCHEMBL3136071 | 0.86 | FNTA (0.55) | FNTAFNTBGRIA2GRIA4ALDH1A1 | |
| SCHEMBL8281925 | 0.86 | GRIA4 (0.70) | FNTAFNTBGRIA2GRIA4KMT2A | |
| SCHEMBL8282788 | 0.84 | GRIA2 (0.54) | FNTAFNTBGRIA2GRIA4ALDH1A1 | |
| SCHEMBL13522951 | 0.84 | FNTA (0.53) | FNTAFNTBGRIA2GRIA4ALDH1A1 | |
| SCHEMBL3142539 | 0.84 | FNTA (0.53) | FNTAFNTBGRIA2GRIA4ALDH1A1 | |
| SCHEMBL3137856 | 0.84 | GRIA4 (0.75) | FNTAFNTBGRIA2GRIA4ALDH1A1 | |
| SCHEMBL3131093 | 0.83 | FNTA (0.53) | FNTAFNTBGRIA2GRIA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706395-A1 | THIOPHENE AND FURAN COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005070916-A1 | THIOPHENE AND FURAN COMPOUNDS | ELI LILLY AND COMPANY (US) | 2005-08-04 | — | — | WO | disclosed |
| WO-2005070916-A1 | THIOPHENE AND FURAN COMPOUNDS | ELI LILLY AND COMPANY (US) | 2005-08-04 | — | — | WO | disclosed |