SCHEMBL5728048

SCHEMBL5728048

O=S(=O)(O)c1cccc(O)c1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.48
AURKA O14965 2/20 0.44
AURKB Q96GD4 2/20 0.44
CDK2 P24941 2/20 0.44
TTR P02766 2/20 0.42
STAT3 P40763 1/20 0.39
COMT P21964 1/20 0.37
CYP1A2 P05177 1/20 0.37
MYC P01106 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ALOX12 P18054 1/20 0.36
ALDH1A1 P00352 1/20 0.36
PTGES2 Q9H7Z7 1/20 0.36
ATIC P31939 1/20 0.36
MAOA P21397 1/20 0.35
ALPL P05186 1/20 0.35
ALPI P09923 1/20 0.35
ALPG P10696 1/20 0.35
DNMT1 P26358 1/20 0.35
MCL1 Q07820 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29184247 0.98 TSHR (0.46) TSHRAURKAAURKBCDK2TTR
SCHEMBL5373563 0.81 TSHR (0.46) TSHRAURKAAURKBCDK2STAT3
SCHEMBL28052460 0.81 CDK2 (0.47) AURKAAURKBCDK2TTRSTAT3
SCHEMBL562742 0.80 TSHR (0.52) TSHRTTRPTGES2KMT2A
SCHEMBL1955906 0.80 CYP3A4 (0.46) TSHRAURKAAURKBCOMTKDM4E
SCHEMBL1070321 0.78 AURKA (0.44) TSHRAURKAAURKBCDK2TTR
Hydrochloric Acid SCHEMBL942823 0.78 TSHR (0.50) TSHRTTRPTGES2KMT2A
SCHEMBL13278151 0.78 TSHR (0.50) TSHRTTRPTGES2KMT2A
SCHEMBL114040 0.77 CDK2 (0.50) AURKAAURKBCDK2TTRSTAT3
SCHEMBL359454 0.77 AURKA (0.47) TSHRAURKAAURKBCDK2TTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250361399-A1 FLUORESCENT DYES WITH LARGE STOKES SHIFT ROCHE MOLECULAR SYSTEMS INC (US) 2025-11-27 US claimed
EP-4547757-A2 FLUORESCENT DYES WITH LARGE STOKES SHIFT F. Hoffmann-La Roche AG (CH) 2025-05-07 EP claimed
WO-2024002924-A2 FLUORESCENT DYES WITH LARGE STOKES SHIFT F. HOFFMANN-LA ROCHE AG (CH) 2024-01-04 WO claimed
CN-104101573-B The method of beryllium hydroxide separation Sulphochlorophenol S spectrphotometric method for measuring Niobium in Steel content 攀钢集团江油长城特殊钢有限公司 2016-12-07 CN claimed
CN-102830074-B The quantitative analysis method of scandium in titanium slag chlorination discarded object PANZHIHUA UNIVERSITY (CN) 2015-09-16 CN claimed
WO-2015049343-A1 SYSTEM FOR THE DETECTION AND QUANTIFICATION OF A URANIUM ION UNIVERSITE DE LIMOGES (FR) 2015-04-09 WO claimed
US-20250361399-A1 FLUORESCENT DYES WITH LARGE STOKES SHIFT ROCHE MOLECULAR SYSTEMS INC (US) 2025-11-27 US disclosed
WO-2025103220-A1 PYRIDYL ALKOXY PYRIMIDINE COMPOUND AND USE THEREOF 青岛清原化合物有限公司 2025-05-22 WO disclosed
EP-4547757-A2 FLUORESCENT DYES WITH LARGE STOKES SHIFT F. Hoffmann-La Roche AG (CH) 2025-05-07 EP disclosed
CN-110494443-B Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds and cell targeting molecules for site-specific conjugation 分子模板公司 2024-12-06 CN disclosed
CN-110475776-B Tricyclic carboxamides for combating arthropods 拜耳作物科学股份公司 2024-03-19 CN disclosed
WO-2024002924-A2 FLUORESCENT DYES WITH LARGE STOKES SHIFT F. HOFFMANN-LA ROCHE AG (CH) 2024-01-04 WO disclosed
CN-114773439-A Shiga toxin A subunit effector polypeptides, shiga toxin effector scaffolds and cell targeting molecules for site-specific conjugation 分子模板公司 2022-07-22 CN disclosed
EP-1146062-B1 Method of producing crosslinkable silyl group-containing polyoxyalkylene polymers KANEKA CORP (JP) 2006-12-20 EP disclosed
US-6503995-B2 Hydrosilation KANEKA CORPORATION (JP) 2003-01-07 US disclosed
US-20020013427-A1 Method of producing crosslinkable silyl group-containing polyoxyalkylene polymers KANEKA CORPORATION (JP) 2002-01-31 US disclosed
EP-1146062-A1 Method of producing crosslinkable silyl group-containing polyoxyalkylene polymers Kaneka Corporation (JP) 2001-10-17 EP disclosed
US-5790627-A Method and apparatus for observing a specimen using an X-ray microscope RESEARCH DEVELOPMENT CORP. (JP) 1998-08-04 US disclosed
US-4931549-A Process for aryl-quinone and aryl-naphthoquinone diazide sulfonic acids HOECHST CELANESE CORPORATION (US) 1990-06-05 US disclosed
EP-0283898-A2 Preparation process of aryldiazidsulfonic acids HOECHST CELANESE CORPORATION (US) 1988-09-28 EP disclosed