Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5725585 | 1.00 | CAPN1 (0.33) | CAPN1CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL5725724 | 0.87 | CCNE1 (0.35) | CAPN1CCNE1CDK2CCNE2CDK1 | |
| SCHEMBL5728145 | 0.86 | CCNE1 (0.32) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL5726079 | 0.86 | CCNE1 (0.32) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL5727425 | 0.84 | CAPN1 (0.33) | CAPN1CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL5725975 | 0.84 | CAPN1 (0.33) | CAPN1CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL7506760 | 0.84 | CCNE1 (0.32) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL5725337 | 0.82 | CAPN1 (0.36) | CAPN1CCNE1CDK2CCNE2 | |
| SCHEMBL5727873 | 0.82 | CAPN1 (0.36) | CAPN1CCNE1CDK2CCNE2 | |
| SCHEMBL5725520 | 0.73 | GSK3B (0.37) | CCNE1CDK2CDK1CDK4CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087951-B9 | CARBON SUBSTITUTED AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-09-13 | — | — | EP | claimed |
| EP-1087951-B1 | CARBON SUBSTITUTED AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2005-02-09 | — | — | EP | claimed |