Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | GLS | O94925 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741246 | 0.91 | GRM2 (0.40) | GRM2L3MBTL1HDAC1NAMPTGLS | |
| SCHEMBL29924728 | 0.86 | GRM2 (0.49) | GRM2L3MBTL1HDAC1NAMPTGLS | |
| SCHEMBL12231247 | 0.86 | GRM2 (0.49) | GRM2L3MBTL1HDAC1NAMPTGLS | |
| SCHEMBL24822620 | 0.81 | GRM2 (0.44) | GRM2L3MBTL1HDAC1NAMPTGAA | |
| SCHEMBL12231326 | 0.80 | GRM2 (0.43) | GRM2L3MBTL1HDAC1NAMPTGAA | |
| SCHEMBL29769069 | 0.80 | GRM2 (0.49) | GRM2L3MBTL1HDAC1NAMPTGLS | |
| SCHEMBL24999627 | 0.80 | GRM2 (0.49) | GRM2L3MBTL1HDAC1NAMPTGLS | |
| SCHEMBL21090329 | 0.79 | GRM2 (0.49) | GRM2L3MBTL1HDAC1NAMPTGLS | |
| SCHEMBL6371286 | 0.79 | TDP1 (0.43) | GRM2L3MBTL1NAMPTGLSKDM4A | |
| SCHEMBL26828546 | 0.78 | EPHX2 (0.42) | GRM2L3MBTL1HDAC1NAMPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720836-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005082859-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2005-09-09 | — | — | WO | disclosed |