Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 13/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7042466 | 0.92 | NPY1R (0.83) | NPY1RPI4KBKDM4EMAPK1HSD17B10 | |
| SCHEMBL5729134 | 0.90 | NPY1R (0.85) | NPY1RMEN1KMT2AATMRAB9A | |
| SCHEMBL5729215 | 0.90 | NPY1R (1.00) | NPY1RMEN1KMT2AATMRAB9A | |
| SCHEMBL5728933 | 0.90 | NPY1R (0.83) | NPY1RMEN1KMT2AATMRAB9A | |
| SCHEMBL5729799 | 0.89 | NPY1R (0.98) | NPY1RMEN1KMT2AATMRAB9A | |
| SCHEMBL5728776 | 0.88 | NPY1R (0.85) | NPY1RMEN1KMT2AATMRAB9A | |
| SCHEMBL7491733 | 0.83 | NPY1R (0.82) | NPY1RMEN1KMT2API4KBKDM4E | |
| SCHEMBL1594426 | 0.83 | NPY1R (0.82) | NPY1RMEN1KMT2API4KBKDM4E | |
| SCHEMBL1593476 | 0.83 | NPY1R (0.82) | NPY1RMEN1KMT2API4KBKDM4E | |
| SCHEMBL1594403 | 0.82 | NPY1R (0.81) | NPY1RMEN1KMT2API4KBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218381-B1 | AMINO SUBSTITUTED PYRAZOLO¬1,5-a|-1,5-PYRIMIDINES AND PYRAZOLO¬1,5-a|-1,3,5-TRIAZINES | NEUROGEN CORP (US) | 2006-12-06 | — | — | EP | disclosed |
| US-6476038-B1 | Amino substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines | NEUROGEN CORPORATION | 2002-11-05 | — | — | US | disclosed |
| EP-1218381-A2 | AMINO SUBSTITUTED PYRAZOLO 1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO 1,5-a]-1,3,5-TRIAZINES | NEUROGEN CORPORATION (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001023388-A2 | AMINO SUBSTITUTED PYRAZOLO[1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO[1,5-a]-1,3,5-TRIAZINES | NEUROGEN CORPORATION (US) | 2001-04-05 | — | — | WO | disclosed |