Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 7/20 | 0.39 |
| ▸ | CYP21A2 | P08686 | 6/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729383 | 1.00 | LSS (0.42) | LSSTSHRCYP17A1CYP21A2CYP11B1 | |
| SCHEMBL6804496 | 0.91 | KMT2A (0.48) | TSHRCYP17A1CYP21A2CYP11B1F10 | |
| SCHEMBL6796805 | 0.91 | F10 (0.47) | TSHRCYP17A1CYP21A2CYP11B1F10 | |
| SCHEMBL6796799 | 0.91 | F10 (0.47) | TSHRCYP17A1CYP21A2CYP11B1F10 | |
| SCHEMBL5728929 | 0.91 | USP2 (0.43) | LSSTSHRCYP17A1CYP21A2CYP11B1 | |
| SCHEMBL6804493 | 0.91 | KMT2A (0.48) | TSHRCYP17A1CYP21A2CYP11B1F10 | |
| SCHEMBL5728932 | 0.91 | USP2 (0.43) | LSSTSHRCYP17A1CYP21A2CYP11B1 | |
| SCHEMBL5731138 | 0.88 | GAA (0.51) | TSHRCYP17A1CYP21A2CYP11B1F10 | |
| SCHEMBL5731142 | 0.88 | GAA (0.51) | TSHRCYP17A1CYP21A2CYP11B1F10 | |
| SCHEMBL5730605 | 0.83 | LSS (0.58) | LSSF10CYP3A4LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1188755-B1 | ACYLHYDRAZINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2006-05-03 | — | — | EP | disclosed |
| US-6723722-B1 | BLOOD COAGULATION FACTOR X INHIBITORS; ANTICOAGULANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2004-04-20 | — | — | US | disclosed |
| EP-1188755-A1 | ACYLHYDRAZINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-20 | — | — | EP | disclosed |