Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25336065 | 0.92 | MEN1 (0.52) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL955547 | 0.83 | MEN1 (0.55) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL2674901 | 0.83 | MEN1 (0.51) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL3902852 | 0.82 | SMN1; SMN2 (0.56) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL5836154 | 0.82 | MEN1 (0.53) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL379160 | 0.82 | MEN1 (0.76) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL4814264 | 0.82 | MEN1 (0.76) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL7393652 | 0.82 | MEN1 (0.76) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL3970912 | 0.82 | MEN1 (0.76) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL8386105 | 0.81 | KMT2A (0.52) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1188755-B1 | ACYLHYDRAZINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2006-05-03 | — | — | EP | disclosed |
| US-6723722-B1 | BLOOD COAGULATION FACTOR X INHIBITORS; ANTICOAGULANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2004-04-20 | — | — | US | disclosed |
| EP-1188755-A1 | ACYLHYDRAZINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-20 | — | — | EP | disclosed |