Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729959 | 0.90 | GCGR (0.59) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL5730444 | 0.88 | GCGR (0.57) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL5730084 | 0.87 | GCGR (0.65) | GCGRALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL4037776 | 0.82 | GCGR (0.59) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL4036939 | 0.80 | GCGR (0.78) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL2650404 | 0.76 | GCGR (0.72) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL4040489 | 0.75 | GCGR (0.60) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL2647850 | 0.74 | GCGR (1.00) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL4042212 | 0.74 | GCGR (0.59) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL4040294 | 0.73 | GCGR (0.66) | GCGRALDH1A1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-A4 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2006-05-31 | — | — | EP | claimed |
| EP-1549655-A2 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 2005-07-06 | — | — | EP | claimed |
| WO-2004024065-A2 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2004-03-25 | — | — | WO | claimed |