Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10270824 | 0.81 | MAPK1 (0.48) | MAPK1MAPTPOLBPKMRAB9A | |
| SCHEMBL571937 | 0.81 | MAPK1 (0.48) | MAPK1MAPTPOLBPKMRAB9A | |
| SCHEMBL2033579 | 0.74 | MAPK1 (0.60) | MAPK1MAPTPOLBPKMRAB9A | |
| SCHEMBL573126 | 0.73 | MAPK1 (0.47) | MAPK1MAPTPOLBPKMRAB9A | |
| SCHEMBL572673 | 0.73 | MAPK1 (0.47) | MAPK1MAPTPOLBPKMRAB9A | |
| SCHEMBL572221 | 0.73 | MAPK1 (0.47) | MAPK1MAPTPOLBPKMRAB9A | |
| SCHEMBL20985374 | 0.72 | MAPK1 (0.56) | MAPK1MAPTPOLBPKMRAB9A | |
| SCHEMBL20985373 | 0.72 | MAPK1 (0.56) | MAPK1MAPTPOLBPKMRAB9A | |
| SCHEMBL573330 | 0.72 | ALK (0.49) | MAPK1 | |
| SCHEMBL572397 | 0.72 | ALK (0.49) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611784-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | Amgen, Inc (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012018668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2012-02-09 | — | — | WO | disclosed |