Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 18/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723773 | 0.96 | TRPV1 (0.79) | TRPV1 | |
| SCHEMBL30753826 | 0.88 | TRPV1 (0.67) | TRPV1 | |
| SCHEMBL2724826 | 0.88 | TRPV1 (0.67) | TRPV1 | |
| SCHEMBL2724894 | 0.88 | TRPV1 (0.67) | TRPV1 | |
| SCHEMBL2727164 | 0.86 | TRPV1 (0.79) | TRPV1 | |
| SCHEMBL2723660 | 0.86 | TRPV1 (0.79) | TRPV1 | |
| SCHEMBL2724621 | 0.85 | TRPV1 (0.62) | TRPV1 | |
| SCHEMBL2723776 | 0.85 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL2725244 | 0.85 | TRPV1 (0.59) | TRPV1 | |
| SCHEMBL31679069 | 0.85 | TRPV1 (0.59) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682141-A1 | 4-FLUORO-4-(PYRIDIN-2-YL)-PIPERIDINE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) FOR THE TREATMENT OF PAIN | MERCK SHARP & DOHME LTD. (GB) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005051390-A1 | E-FLUORO-4-(PYRIDIN-2-YL)-PIPERIDINE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) FOR THE TREATMENT OF PAIN | MERCK SHARP & DOHME LIMITED (GB) | 2005-06-09 | — | — | WO | disclosed |