Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SGK1 | O00141 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5732443 | 1.00 | ADORA1 (0.40) | ADORA1ADORA2AADORA3ADORA2BIGF1R | |
| SCHEMBL6076669 | 0.98 | ADORA1 (0.40) | ADORA1ADORA2AADORA3ADORA2BIGF1R | |
| SCHEMBL6076663 | 0.98 | ADORA1 (0.40) | ADORA1ADORA2AADORA3ADORA2BIGF1R | |
| SCHEMBL6095949 | 0.94 | SGK1 (0.39) | ADORA1ADORA2AADORA3ADORA2BIGF1R | |
| SCHEMBL6095947 | 0.94 | SGK1 (0.39) | ADORA1ADORA2AADORA3ADORA2BIGF1R | |
| SCHEMBL5732894 | 0.90 | IGF1R (0.42) | ADORA1ADORA2AADORA3ADORA2BIGF1R | |
| SCHEMBL5733329 | 0.88 | ADORA2A (0.45) | ADORA1ADORA2AADORA3ADORA2BIGF1R | |
| SCHEMBL5733328 | 0.88 | ADORA2A (0.45) | ADORA1ADORA2AADORA3ADORA2BIGF1R | |
| SCHEMBL6075854 | 0.86 | PDE5A (0.40) | IGF1RKMT2A | |
| SCHEMBL6075639 | 0.86 | ADORA1 (0.47) | ADORA1ADORA2AADORA3ADORA2BIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138398-B2 | Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their preparation, their use and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-21 | — | — | US | claimed |
| EP-1131302-B1 | SUBSTITUTED 4-AMINO-2-ARYL-CYCLOPENTA [D]PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | SANOFI AVENTIS DEUTSCHLAND (DE) | 2006-02-01 | — | — | EP | claimed |