Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5733083 | 0.92 | TOP2A (0.47) | TOP2ATOP2BKCNH2POLBCACNA1F | |
| SCHEMBL15828601 | 0.91 | TOP2A (0.45) | TOP2ATOP2BKCNH2POLBCACNA1F | |
| SCHEMBL15828600 | 0.89 | TOP2A (0.44) | TOP2ATOP2BKCNH2POLBALDH1A1 | |
| SCHEMBL5733827 | 0.88 | TOP2A (0.47) | TOP2ATOP2BKCNH2POLBCACNA1F | |
| SCHEMBL5732959 | 0.86 | TOP2A (0.50) | TOP2ATOP2BKCNH2POLBKDM4E | |
| SCHEMBL5733255 | 0.86 | TOP2A (0.48) | TOP2ATOP2BKCNH2POLBCACNA1F | |
| SCHEMBL5732577 | 0.85 | TOP2A (0.52) | TOP2ATOP2BKCNH2POLBKDM4E | |
| SCHEMBL5733481 | 0.85 | TOP2A (0.45) | TOP2ATOP2BKCNH2POLBKDM4E | |
| SCHEMBL5733920 | 0.83 | TOP2A (0.45) | TOP2ATOP2BKCNH2POLBKDM4E | |
| SCHEMBL5733843 | 0.83 | TOP2A (0.49) | TOP2ATOP2BKCNH2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070713-B1 | QUINOLONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF | TOYAMA CHEMICAL CO LTD (JP) | 2006-10-18 | — | — | EP | disclosed |
| US-6335447-B1 | BACTERICIDES | TOYAMA CHEMICAL CO., LTD. (JP) | 2002-01-01 | — | — | US | disclosed |
| EP-1070713-A1 | QUINOLONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2001-01-24 | — | — | EP | disclosed |