Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.84 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.77 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.67 |
| ▸ | ABL1 | P00519 | 3/20 | 0.67 |
| ▸ | KIT | P10721 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12245436 | 0.92 | MAPK14 (1.00) | MAPK14DDR2MAPK13MAPK12MAPK11 | |
| SCHEMBL12245435 | 0.87 | MAPK14 (1.00) | MAPK14DDR2MAPK13MAPK12MAPK11 | |
| SCHEMBL3300214 | 0.87 | MAPK14 (0.84) | MAPK14DDR2MAPK13MAPK12MAPK11 | |
| SCHEMBL2082226 | 0.86 | MAPK14 (0.77) | MAPK14DDR2MAPK13MAPK12MAPK11 | |
| SCHEMBL5733636 | 0.86 | MAPK14 (0.81) | MAPK14DDR2MAPK13MAPK12MAPK11 | |
| SCHEMBL4465314 | 0.85 | MAPK14 (0.83) | MAPK14DDR2MAPK13MAPK12MAPK11 | |
| SCHEMBL938408 | 0.84 | MAPK14 (0.74) | MAPK14DDR2MAPK13MAPK12MAPK11 | |
| SCHEMBL16866510 | 0.83 | MAPK13 (0.83) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1410153 | 0.83 | MAPK13 (0.79) | MAPK14DDR2MAPK13MAPK12MAPK11 | |
| SCHEMBL5733849 | 0.82 | MAPK14 (0.75) | MAPK14DDR2MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056725-B1 | INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2006-06-07 | — | — | EP | claimed |