Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 1.00 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | ABL2 | P42684 | 1/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.68 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.68 |
| ▸ | RAF1 | P04049 | 1/20 | 0.65 |
| ▸ | BRAF | P15056 | 1/20 | 0.65 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4298900 | 0.88 | MAPK14 (0.78) | MAPK14MAPK11ABL1ABL2MAPK8 | |
| SCHEMBL2616949 | 0.87 | MAPK14 (1.00) | MAPK14MAPK11ABL1ABL2MAPK8 | |
| SCHEMBL4472390 | 0.87 | MAPK14 (0.77) | MAPK14MAPK11ABL1ABL2MAPK8 | |
| SCHEMBL5743898 | 0.84 | MAPK14 (1.00) | MAPK14MAPK11ABL1ABL2MAPK8 | |
| SCHEMBL5733076 | 0.84 | MAPK14 (1.00) | MAPK14MAPK11ABL1ABL2MAPK8 | |
| SCHEMBL668606 | 0.83 | MAPK14 (1.00) | MAPK14MAPK11ABL1ABL2MAPK8 | |
| SCHEMBL2616952 | 0.83 | MAPK14 (0.80) | MAPK14MAPK11ABL1ABL2MAPK8 | |
| SCHEMBL5733215 | 0.83 | MAPK14 (0.72) | MAPK14MAPK11ABL1ABL2MAPK8 | |
| SCHEMBL937402 | 0.82 | MAPK14 (1.00) | MAPK14MAPK11ABL1ABL2MAPK8 | |
| SCHEMBL2083328 | 0.82 | MAPK14 (0.85) | MAPK14MAPK11ABL1ABL2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056725-B1 | INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2006-06-07 | — | — | EP | claimed |