SCHEMBL5734058

SCHEMBL5734058

[CH2]Cc1c(NC(=O)c2cc3cc(NC(=O)c4cc5ccocc-5c4)ccc3[nH]2)cc(N(C=O)OCc2ccccc2)c2ccccc12

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LRRK2 Q5S007 2/20 0.37
PPARD Q03181 1/20 0.37
NR1H4 Q96RI1 1/20 0.37
HDAC2 Q92769 5/20 0.36
NHERF1 O14745 1/20 0.34
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
PIN1 Q13526 1/20 0.32
HDAC1 Q13547 1/20 0.32
PYGL P06737 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6179455 0.93 PPARD (0.38) LRRK2PPARDNR1H4HDAC2NHERF1
SCHEMBL5734516 0.92 LRRK2 (0.38) LRRK2PPARDNR1H4HDAC2NHERF1
SCHEMBL6179806 0.90 HDAC2 (0.37) LRRK2PPARDNR1H4HDAC2NHERF1
SCHEMBL6182772 0.90 LRRK2 (0.36) LRRK2PPARDNR1H4HDAC2NHERF1
SCHEMBL5733235 0.73 HDAC2 (0.47) LRRK2PPARDNR1H4HDAC2NHERF1
SCHEMBL6178175 0.73 KDM4E (0.51) HDAC2HDAC1PYGL
SCHEMBL5733608 0.73 KDM4E (0.51) HDAC2HDAC1PYGL
SCHEMBL5732905 0.71 KDM4E (0.48) HDAC2HDAC1PYGL
SCHEMBL5733738 0.70 KDM4E (0.47) HDAC2HDAC1PYGL
SCHEMBL5732990 0.69 LRRK2 (0.38) LRRK2PPARDNR1H4HDAC2NHERF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1320522-B8 COMPOSITIONS AND METHODS OF THE USE THEREOF ACHIRAL ANALOGUES OF CC-1065 AND THE DUOCARMYCINS LEE MOSES (US) 2006-02-01 EP disclosed
EP-1320522-A2 COMPOSITIONS AND METHODS OF THE USE THEREOF ACHIRAL ANALOGUES OF CC-1065 AND THE DUOCARMYCINS TAIHO PHARMACEUTICAL CO., LTD. (JP) 2003-06-25 EP disclosed
WO-2002030894-A2 COMPOSITIONS AND METHODS OF THE USE THEREOF ACHIRAL ANALOGUES OF CC-1065 AND THE DUOCARMYCINS TAIHO PHARMACEUTICAL CO., LTD. (JP) 2002-04-18 WO disclosed