Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026524 | 1.00 | BCHE (0.60) | BCHEKMT2AKDM4EMAPTPKM | |
| SCHEMBL6392691 | 0.89 | KMT2A (0.70) | BCHEKMT2AKDM4C | |
| SCHEMBL4028744 | 0.89 | BCHE (0.61) | BCHEKMT2AKDM4EMAPTPKM | |
| SCHEMBL4027162 | 0.89 | BCHE (0.64) | BCHEKMT2AKDM4EMAPTPKM | |
| SCHEMBL5734195 | 0.88 | GRIN2D (0.64) | BCHEKMT2AKDM4EMAPTPKM | |
| SCHEMBL4026150 | 0.88 | GRIN2D (0.64) | BCHEKMT2AKDM4EMAPTPKM | |
| SCHEMBL4029481 | 0.88 | KDM4C (0.67) | BCHEKMT2AKDM4EMAPTPKM | |
| SCHEMBL13344570 | 0.88 | BCHE (0.77) | BCHEKDM4EMAPTPKM | |
| SCHEMBL6374574 | 0.88 | KMT2A (0.64) | BCHEKMT2AKDM4EKDM4CMEN1 | |
| SCHEMBL13344569 | 0.88 | BCHE (0.77) | BCHEKDM4EMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611104-A1 | TETRAHYDROISOQUINOLYL ACETAMIDE DERIVATIVES FOR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004085403-A1 | TETRAHYDROISOQUINOLYL ACETAMIDE DERIVATIVES FOR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-10-07 | — | — | WO | disclosed |